| First Quarter |
| Team | Down | Spot | Play | KC | SD |
| KC | | | Ryan Succop kicks off to the SD0. Touchback. | | |
| SD | 1st&10 | SD20 | Ryan Mathews rush up the middle for 8 yards to the SD28. Tackled by Eric Berry and Tamba Hali. | | |
| SD | 2nd&2 | SD28 | Ryan Mathews rush to the left for 1 yard to the SD29. Tackled by Glenn Dorsey and Dontari Poe. | | |
| SD | 3rd&1 | SD29 | Penalty: False Start on San Diego (Jared Gaither) -4 yards. | | |
| SD | 3rd&5 | SD25 | Philip Rivers pass to the left to Seyi Ajirotutu for 28 yards to the KC47. Tackled by Eric Berry. | | |
| SD | 1st&10 | KC47 | Philip Rivers pass to the left to Antonio Gates for 21 yards to the KC26. Tackled by Kendrick Lewis. | | |
| SD | 1st&10 | KC26 | Philip Rivers pass to the right to Malcom Floyd for 7 yards to the KC19. Tackled by Jovan Belcher. | | |
| SD | 2nd&3 | KC19 | Ryan Mathews rush to the right for 5 yards to the KC14. Tackled by Justin Houston and Dontari Poe. | | |
| SD | 1st&10 | KC14 | Philip Rivers pass to the left to Antonio Gates for 14 yards for a TOUCHDOWN. | | |
| SD | | | Nick Novak extra point is good. | | |
| SD | | | Drive Stats: 7 plays, 80 yards, 3min 44sec | 0 | 7 |
| Team | Down | Spot | Play | KC | SD |
| SD | | | Nick Novak kicks off to the KC0. Shaun Draughn return for 5 yards to KC13. Tackled by Jackie Battle. | | |
| KC | 1st&10 | KC13 | Jamaal Charles rush to the right for 8 yards to the KC21. Tackled by Takeo Spikes and Atari Bigby. | | |
| KC | 2nd&2 | KC21 | Matt Cassel rush to the left for 4 yards to the KC25. Tackled by Antoine Cason. | | |
| KC | 1st&10 | KC25 | Jamaal Charles rush to the right for 2 yards to the KC27. Tackled by Aubrayo Franklin and Takeo Spikes. | | |
| KC | 2nd&8 | KC27 | Matt Cassel incomplete pass to the left intended for Jamaal Charles defensed by Corey Liuget. | | |
| KC | 3rd&8 | KC27 | Matt Cassel pass to the right to Dwayne Bowe for 14 yards to the KC41. Tackled by Shaun Phillips and Atari Bigby. | | |
| KC | 1st&10 | KC41 | Dexter McCluster rush to the right for a loss of 2 yards to the KC39. Tackled by Quentin Jammer. | | |
| KC | 2nd&12 | KC39 | Matt Cassel incomplete pass to the right intended for Terrance Copper. | | |
| KC | 3rd&12 | KC39 | Matt Cassel pass to the right to Dexter McCluster for 12 yards to the SD49. Tackled by Marcus Gilchrist. | | |
| KC | 1st&10 | SD49 | Jamaal Charles rush to the left for no gain to the SD49. Tackled by Melvin Ingram. | | |
| KC | 2nd&10 | SD49 | Matt Cassel incomplete pass to the left intended for Jon Baldwin. | | |
| KC | 3rd&10 | SD49 | Matt Cassel pass to the left to Dwayne Bowe for 11 yards to the SD38. Tackled by Eric Weddle. | | |
| KC | 1st&10 | SD38 | Peyton Hillis rush up the middle for 2 yards to the SD36. Tackled by Donald Butler and Takeo Spikes. | | |
| KC | 2nd&8 | SD36 | Matt Cassel pass to the middle to Dwayne Bowe for 7 yards to the SD29. Tackled by Donald Butler. | | |
| KC | 3rd&1 | SD29 | Peyton Hillis rush to the right for 1 yard to the SD28. Tackled by Atari Bigby and Takeo Spikes. | | |
| KC | 1st&10 | SD28 | Jamaal Charles rush to the left for a loss of 5 yards to the SD33. Tackled by Eric Weddle. | | |
| KC | 2nd&15 | SD33 | Matt Cassel incomplete pass to the right intended for Dexter McCluster. | | |
| KC | 3rd&15 | SD33 | Matt Cassel pass to the right to Dwayne Bowe for 10 yards to the SD23. Tackled by Demorrio Williams and Melvin Ingram. FUMBLE, recovered by SD (Quentin Jammer). Tackled by Eric Winston. | | |
| Team | Down | Spot | Play | KC | SD |
| SD | 1st&10 | SD22 | Ryan Mathews rush to the left for 4 yards to the SD26. Tackled by Derrick Johnson. | | |
| SD | 2nd&6 | SD26 | Ryan Mathews rush to the left for 4 yards to the SD30. Tackled by Jovan Belcher and Tamba Hali. | | |
| SD | 3rd&2 | SD30 | Penalty: Offside on Kansas City (Justin Houston) 5 yards. | | |
| SD | 1st&10 | SD35 | Penalty: False Start on San Diego (Jared Gaither) -5 yards. | | |
| SD | 1st&15 | SD30 | Philip Rivers pass to the left to Danario Alexander for 11 yards to the SD41. Tackled by Javier Arenas. | | |
| |
| Second Quarter |
| Team | Down | Spot | Play | KC | SD |
| SD | 2nd&4 | SD41 | Ryan Mathews rush to the right for 3 yards to the SD44. Tackled by Brandon Flowers and Justin Houston. | | |
| SD | 3rd&1 | SD44 | Jackie Battle rush to the right for 3 yards to the SD47. Tackled by Derrick Johnson. | | |
| SD | 1st&10 | SD47 | Philip Rivers pass to the right to Ryan Mathews for 6 yards to the KC47. Tackled by Justin Houston. | | |
| SD | 2nd&4 | KC47 | Ryan Mathews rush to the left for 2 yards to the KC45. Tackled by Javier Arenas. | | |
| SD | 3rd&2 | KC45 | Philip Rivers pass to the left to Danario Alexander for 30 yards to the KC15. Tackled by Abram Elam and Derrick Johnson. | | |
| SD | 1st&10 | KC15 | Ryan Mathews rush to the left for a loss of 2 yards to the KC17. Tackled by Javier Arenas. | | |
| SD | 2nd&12 | KC17 | Philip Rivers pass to the left to Ronnie Brown for 3 yards to the KC14. Tackled by Tamba Hali. | | |
| SD | 3rd&9 | KC14 | San Diego Chargers timeout. | | |
| SD | 3rd&9 | KC14 | Philip Rivers pass to the left to Ronnie Brown for 7 yards to the KC7. Tackled by Eric Berry and Travis Daniels. | | |
| SD | 4th&2 | KC7 | Nick Novak 25 yard field goal attempt is GOOD. Holder: Mike Scifres. | | |
| SD | | | Drive Stats: 12 plays, 71 yards, 8min 8sec | 0 | 10 |
| Team | Down | Spot | Play | KC | SD |
| SD | | | Nick Novak kicks off to the KC0. Shaun Draughn return for 28 yards to KC20. Tackled by Atari Bigby. | | |
| KC | 1st&10 | KC20 | Jamaal Charles rush to the right for no gain to the KC20. Tackled by Aubrayo Franklin and Atari Bigby. | | |
| KC | 2nd&10 | KC20 | Matt Cassel rush up the middle for 8 yards to the KC28. Tackled by Donald Butler. | | |
| KC | 3rd&2 | KC28 | Kansas City Chiefs timeout. | | |
| KC | 3rd&2 | KC28 | Matt Cassel pass to the left to Dwayne Bowe for 9 yards to the KC37. Tackled by Antoine Cason. | | |
| KC | 1st&10 | KC37 | Jamaal Charles rush to the right for 4 yards to the KC41. Tackled by Corey Liuget and Vaughn Martin. | | |
| KC | 2nd&6 | KC41 | Peyton Hillis rush to the right for 1 yard to the KC42. Tackled by Eric Weddle and Vaughn Martin. | | |
| KC | 3rd&5 | KC42 | Penalty: Offside on San Diego (Antwan Barnes) 5 yards. | | |
| KC | 1st&10 | KC47 | Dexter McCluster rush to the right for 13 yards to the SD40. Tackled by Atari Bigby. | | |
| KC | 1st&10 | SD40 | Matt Cassel pass to the middle to Jamaal Charles for 3 yards to the SD37. Tackled by Jarret Johnson and Corey Liuget. | | |
| KC | 2nd&7 | SD37 | Dexter McCluster rush up the middle for 6 yards to the SD31. Tackled by Corey Liuget. | | |
| KC | 3rd&1 | SD31 | Peyton Hillis rush up the middle for no gain to the SD31. Tackled by Donald Butler and Antonio Garay. | | |
| KC | 4th&1 | SD31 | Ryan Succop 49 yard field goal attempt is GOOD. Holder: Dustin Colquitt. | | |
| KC | | | Drive Stats: 10 plays, 49 yards, 6min 19sec | 3 | 10 |
| Team | Down | Spot | Play | KC | SD |
| KC | | | Ryan Succop kicks off to the SD0. Curtis Brinkley return for 24 yards to SD22. Tackled by Terrance Copper. Penalty: Unnecessary Roughness on Kansas City (Javier Arenas) 15 yards. | | |
| SD | 1st&10 | SD37 | Philip Rivers pass to the left to Malcom Floyd for 16 yards to the KC47. Tackled by Javier Arenas. | | |
| SD | 1st&10 | KC47 | Philip Rivers pass to the left to Malcom Floyd for 12 yards to the KC35. Tackled by Javier Arenas. | | |
| SD | 1st&10 | KC35 | Two Minute Warning. | | |
| SD | 1st&10 | KC35 | Philip Rivers pass to the right to Ronnie Brown for 9 yards to the KC26. Tackled by Javier Arenas. | | |
| SD | 2nd&1 | KC26 | Ronnie Brown rush up the middle for 6 yards to the KC20. Tackled by Derrick Johnson and Justin Houston. | | |
| SD | 1st&10 | KC20 | Philip Rivers pass to the middle to Antonio Gates for 8 yards to the KC12. Tackled by Derrick Johnson and Eric Berry. | | |
| SD | 2nd&2 | KC12 | Ronnie Brown rush up the middle for 4 yards to the KC8. Tackled by Justin Houston and Javier Arenas. | | |
| SD | 1st&8 | KC8 | San Diego Chargers timeout. | | |
| SD | 1st&8 | KC8 | Philip Rivers incomplete pass to the left. | | |
| SD | 2nd&8 | KC8 | Philip Rivers pass to the left to Ronnie Brown for 7 yards to the KC1. Tackled by Justin Houston and Eric Berry. | | |
| SD | 3rd&1 | KC1 | Kansas City Chiefs timeout. | | |
| SD | 3rd&1 | KC1 | Philip Rivers pass intended for Dante Rosario INTERCEPTED by Eric Berry. No return. | | |
| Team | Down | Spot | Play | KC | SD |
| KC | 1st&10 | KC20 | Matt Cassel rush up the middle for a loss of 1 yard to the KC19. | | |
| Team | Down | Spot | Play | KC | SD |
| |
| Third Quarter |
| Team | Down | Spot | Play | KC | SD |
| SD | | | Nick Novak kicks off to the KC0. Shaun Draughn return for 29 yards to KC26. Tackled by Darrell Stuckey and Atari Bigby. | | |
| KC | 1st&10 | KC26 | Jamaal Charles rush to the right for a loss of 1 yard to the KC25. Tackled by Donald Butler. | | |
| KC | 2nd&11 | KC25 | Matt Cassel pass to the left to Dwayne Bowe for 10 yards to the KC35. Tackled by Antoine Cason. | | |
| KC | 3rd&1 | KC35 | Dexter McCluster rush up the middle for no gain to the KC35. Tackled by Donald Butler. | | |
| KC | 4th&1 | KC35 | Dustin Colquitt punts for 54 yards to SD11. Eric Weddle - no return. | | |
| Team | Down | Spot | Play | KC | SD |
| SD | | | FUMBLE, recovered by SD (Eric Weddle). | | |
| Team | Down | Spot | Play | KC | SD |
| KC | 4th&1 | KC35 | Dustin Colquitt punts for 43 yards to SD22. Eric Weddle return for 2 yards to SD24. Tackled by Jalil Brown. FUMBLE, recovered by KC (Cory Greenwood). Tackled by Jackie Battle. | | |
| KC | 1st&10 | SD24 | Matt Cassel incomplete pass to the right intended for Dwayne Bowe. | | |
| KC | 2nd&10 | SD24 | Jamaal Charles rush up the middle for 3 yards to the SD21. Tackled by Corey Liuget. | | |
| KC | 3rd&7 | SD21 | Matt Cassel incomplete pass to the right intended for Dwayne Bowe. | | |
| KC | 4th&7 | SD21 | 39 yard field goal attempt by Ryan Succop is NO GOOD. Holder: Dustin Colquitt. | | |
| SD | 1st&10 | SD29 | Ryan Mathews rush to the right for 2 yards to the SD31. Tackled by Justin Houston. | | |
| SD | 2nd&8 | SD31 | Philip Rivers pass to the left to Ronnie Brown for 9 yards to the SD40. Tackled by Javier Arenas. | | |
| SD | 1st&10 | SD40 | Philip Rivers pass to the left to Danario Alexander for 20 yards to the KC40. Tackled by Travis Daniels. | | |
| SD | 1st&10 | KC40 | Philip Rivers sacked at KC44 for a loss of 4 yards by Tamba Hali. | | |
| SD | 2nd&14 | KC44 | Penalty: Holding on San Diego (Jared Gaither) -10 yards. | | |
| SD | 2nd&24 | SD46 | Philip Rivers pass to the right to Ryan Mathews for a loss of 1 yard to the SD45. Tackled by Eric Berry. | | |
| SD | 3rd&25 | SD45 | Ronnie Brown rush up the middle for 10 yards to the KC45. Tackled by Eric Berry. | | |
| SD | 4th&15 | KC45 | Mike Scifres punts for 38 yards to KC7. No return. | | |
| Team | Down | Spot | Play | KC | SD |
| KC | 1st&10 | KC7 | Matt Cassel pass to the right to Dwayne Bowe for 13 yards to the KC20. Tackled by Atari Bigby. | | |
| KC | 1st&10 | KC20 | Jamaal Charles rush up the middle for 10 yards to the KC30. Tackled by Eric Weddle. | | |
| KC | 1st&10 | KC30 | Jamaal Charles rush to the right for 2 yards to the KC32. Tackled by Cam Thomas and Kendall Reyes. | | |
| KC | 2nd&8 | KC32 | Jamaal Charles rush to the left for 15 yards to the KC47. Tackled by Eric Weddle. | | |
| KC | 1st&10 | KC47 | Matt Cassel rush up the middle for 14 yards to the SD39. Tackled by Takeo Spikes. | | |
| KC | 1st&10 | SD39 | Peyton Hillis rush to the right for 11 yards to the SD28. Tackled by Eric Weddle. | | |
| KC | 1st&10 | SD28 | Peyton Hillis rush to the left for a loss of 3 yards to the SD31. Tackled by Melvin Ingram. | | |
| KC | 2nd&13 | SD31 | Penalty: False Start on Kansas City (Branden Albert) -5 yards. | | |
| KC | 2nd&18 | SD36 | Matt Cassel incomplete pass to the right intended for Dexter McCluster defensed by Donald Butler. | | |
| KC | 3rd&18 | SD36 | Matt Cassel pass to the right to Jon Baldwin for 13 yards to the SD23. Tackled by Shareece Wright and Quentin Jammer. | | |
| KC | 4th&5 | SD23 | Ryan Succop 41 yard field goal attempt is GOOD. Holder: Dustin Colquitt. | | |
| KC | | | Drive Stats: 10 plays, 70 yards, 6min 16sec | 6 | 10 |
| Team | Down | Spot | Play | KC | SD |
| KC | | | Ryan Succop kicks off to the SD0. Touchback. | | |
| SD | 1st&10 | SD20 | Ryan Mathews rush up the middle for 31 yards to the KC49. Tackled by Javier Arenas. | | |
| SD | 1st&10 | KC49 | Jackie Battle rush to the left for 11 yards to the KC38. Tackled by Jovan Belcher. | | |
| |
| Fourth Quarter |
| Team | Down | Spot | Play | KC | SD |
| SD | 1st&10 | KC38 | Ryan Mathews rush to the right for 5 yards to the KC33. Tackled by Ropati Pitoitua. | | |
| SD | 2nd&5 | KC33 | Ryan Mathews rush to the left for 2 yards to the KC31. Tackled by Tamba Hali and Ropati Pitoitua. | | |
| SD | 3rd&3 | KC31 | Ronnie Brown rush up the middle for 7 yards to the KC24. Tackled by Tamba Hali and Allen Bailey. | | |
| SD | 1st&10 | KC24 | Ryan Mathews rush to the left for 2 yards to the KC22. Tackled by Tamba Hali and Ropati Pitoitua. | | |
| SD | 2nd&8 | KC22 | San Diego Chargers timeout. | | |
| SD | 2nd&8 | KC22 | Ronnie Brown rush to the left for 9 yards to the KC13. Tackled by Eric Berry. | | |
| SD | 1st&10 | KC13 | Philip Rivers pass to the left to Malcom Floyd for 13 yards for a TOUCHDOWN. | | |
| SD | | | Nick Novak extra point is good. | | |
| SD | | | Drive Stats: 8 plays, 80 yards, 4min 20sec | 6 | 17 |
| Team | Down | Spot | Play | KC | SD |
| SD | | | Nick Novak kicks off to the KC0. Shaun Draughn return for 21 yards to KC16. Tackled by Darrell Stuckey and Andrew Gachkar. Penalty: Face Mask on Kansas City (Donald Stephenson) -8 yards. | | |
| KC | 1st&10 | KC8 | Penalty: False Start on Kansas City (Eric Winston) -4 yards. | | |
| KC | 1st&14 | KC4 | Jamaal Charles rush to the left for 1 yard to the KC5. Tackled by Donald Butler. | | |
| KC | 2nd&13 | KC5 | Matt Cassel sacked at KC0 for a loss of 5 yards by Jarret Johnson. FUMBLE, recovered by SD (Shaun Phillips) for a TOUCHDOWN. | | |
| Team | Down | Spot | Play | KC | SD |
| SD | | | Nick Novak extra point is good. | | |
| SD | | | Drive Stats: 0 plays, 0 yards, 0sec | 6 | 24 |
| Team | Down | Spot | Play | KC | SD |
| SD | | | Nick Novak kicks off to the KC0. Touchback. | | |
| KC | 1st&10 | KC20 | Matt Cassel pass to the left to Jamaal Charles for 22 yards to the KC42. Tackled by Eric Weddle. | | |
| KC | 1st&10 | KC42 | Matt Cassel pass to the right to Dwayne Bowe for 5 yards to the KC47. Tackled by Quentin Jammer. | | |
| KC | 2nd&5 | KC47 | Matt Cassel incomplete pass to the right intended for Dexter McCluster defensed by Corey Lynch. | | |
| KC | 3rd&5 | KC47 | Matt Cassel pass to the left to Dexter McCluster for 5 yards to the SD48. Tackled by Marcus Gilchrist. | | |
| KC | 1st&10 | SD48 | Matt Cassel pass to the middle to Jamaal Charles for 2 yards to the SD46. Tackled by Donald Butler and Corey Lynch. | | |
| KC | 2nd&8 | SD46 | Matt Cassel pass intended for Dexter McCluster INTERCEPTED by Demorrio Williams and returned for 59 yards for a TOUCHDOWN. | | |
| Team | Down | Spot | Play | KC | SD |
| SD | | | Nick Novak extra point is good. | | |
| SD | | | Drive Stats: 0 plays, 0 yards, 0sec | 6 | 31 |
| Team | Down | Spot | Play | KC | SD |
| SD | | | Nick Novak kicks off to the KC0. Touchback. | | |
| KC | 1st&10 | KC20 | Peyton Hillis rush up the middle for 2 yards to the KC22. Tackled by Antwan Barnes and Antonio Garay. | | |
| KC | 2nd&8 | KC22 | Matt Cassel pass to the left to Steve Breaston for 10 yards to the KC32. Tackled by Marcus Gilchrist. | | |
| KC | 1st&10 | KC32 | Matt Cassel incomplete pass to the left. | | |
| KC | 2nd&10 | KC32 | Penalty: Pass Interference on San Diego (Quentin Jammer) 15 yards. | | |
| KC | 1st&10 | KC47 | Kansas City Chiefs timeout. | | |
| KC | 1st&10 | KC47 | Matt Cassel pass to the right to Shaun Draughn for 1 yard to the KC48. Tackled by Quentin Jammer. | | |
| KC | 2nd&9 | KC48 | Matt Cassel pass to the left to Peyton Hillis for 7 yards to the SD45. Tackled by Marcus Gilchrist. | | |
| KC | 3rd&2 | SD45 | Matt Cassel pass to the left to Steve Breaston for 7 yards to the SD38. Tackled by Antoine Cason. | | |
| KC | 1st&10 | SD38 | Matt Cassel rush up the middle for 5 yards to the SD33. Tackled by Marcus Gilchrist. | | |
| KC | 2nd&5 | SD33 | Matt Cassel rush up the middle for 7 yards to the SD26. Tackled by Donald Butler. | | |
| KC | 1st&10 | SD26 | Matt Cassel pass to the left to Shaun Draughn for 20 yards to the SD6. Tackled by Demorrio Williams. | | |
| KC | 1st&6 | SD6 | Shaun Draughn rush up the middle for 6 yards for a TOUCHDOWN. | | |
| KC | | | Ryan Succop extra point is good. | | |
| KC | | | Drive Stats: 10 plays, 80 yards, 4min 7sec | 13 | 31 |
| KC | | | Ryan Succop onside kickoff to the KC40. Onside kick recovered by receving team by Corey Lynch. | | |
| Team | Down | Spot | Play | KC | SD |
| SD | 1st&10 | KC40 | Penalty: False Start on San Diego (Mike Harris) -5 yards. | | |
| SD | 1st&15 | KC45 | Jackie Battle rush to the right for 3 yards to the KC42. Tackled by Justin Houston. | | |
| SD | 2nd&12 | KC42 | Jackie Battle rush up the middle for 3 yards to the KC39. Tackled by Ropati Pitoitua and Tamba Hali. | | |
| SD | 3rd&9 | KC39 | Penalty: Delay of Game on San Diego (Philip Rivers) -5 yards. | | |
| SD | 3rd&14 | KC44 | Ronnie Brown rush up the middle for 2 yards to the KC42. Tackled by Tyson Jackson and Justin Houston. | | |
| SD | 4th&12 | KC42 | Penalty: Delay of Game on San Diego (Mike Scifres) -5 yards. | | |
| SD | 4th&17 | KC47 | Mike Scifres punts for 31 yards to KC16. Dexter McCluster - no return. FUMBLE, recovered by SD (Darrell Stuckey). Tackled by Dexter McCluster. | | |
| SD | | | Two Minute Warning. | | |
| SD | 1st&10 | KC16 | Le'Ron McClain rush up the middle for no gain to the KC16. Tackled by Tamba Hali. | | |
| SD | 2nd&10 | KC16 | Philip Rivers rush up the middle for a loss of 1 yard to the KC17. | | |
| SD | 3rd&11 | KC17 | Philip Rivers rush up the middle for a loss of 1 yard to the KC18. | | |