| First Quarter |
| Team | Down | Spot | Play | StL | SF |
| StL | | | Greg Zuerlein kicks off to the SF0. Ted Ginn Jr. return for 28 yards to SF20. Tackled by Bradley Fletcher. | | |
| SF | 1st&10 | SF20 | Frank Gore rush up the middle for a loss of 1 yard to the SF19. Tackled by Kendall Langford. | | |
| SF | 2nd&11 | SF19 | Alex Smith sacked at SF17 for a loss of 2 yards by Michael Brockers and Robert Quinn. | | |
| SF | 3rd&13 | SF17 | Alex Smith pass to the left to Frank Gore for 4 yards to the SF21. Tackled by Chris Long. | | |
| SF | 4th&9 | SF21 | Andy Lee punts for 41 yards to StL38. Danny Amendola return for 6 yards to StL44. Tackled by C.J. Spillman. Penalty: Illegal Block on St. Louis (Quinton Pointer) -10 yards. | | |
| Team | Down | Spot | Play | StL | SF |
| StL | 1st&10 | StL34 | Steven Jackson rush to the right for 2 yards to the StL36. Tackled by Ray McDonald. | | |
| StL | 2nd&8 | StL36 | Steven Jackson rush up the middle for 10 yards to the StL46. Tackled by Ahmad Brooks. | | |
| StL | 1st&10 | StL46 | Steven Jackson rush to the right for 4 yards to the StL50. Tackled by Ray McDonald. | | |
| StL | 2nd&6 | StL50 | Steven Jackson rush to the left for 7 yards to the SF43. Tackled by Tarell Brown. | | |
| StL | 1st&10 | SF43 | Sam Bradford pass to the right to Danny Amendola for 7 yards to the SF36. Tackled by Donte Whitner. | | |
| StL | 2nd&3 | SF36 | Sam Bradford pass to the right to Brian Quick for 36 yards for a TOUCHDOWN. | | |
| StL | | | Greg Zuerlein extra point is good. | | |
| StL | | | Drive Stats: 6 plays, 66 yards, 3min 23sec | 7 | 0 |
| Team | Down | Spot | Play | StL | SF |
| StL | | | Greg Zuerlein kicks off to the SF0. Ted Ginn Jr. return for 22 yards to SF19. Tackled by Quintin Mikell. | | |
| SF | 1st&10 | SF19 | Penalty: Encroachment on St. Louis (Kendall Langford) 5 yards. | | |
| SF | 1st&5 | SF24 | Frank Gore rush to the left for 8 yards to the SF32. Tackled by Trumaine Johnson. | | |
| SF | 1st&10 | SF32 | Kendall Hunter rush to the left for 4 yards to the SF36. Tackled by James Laurinaitis. | | |
| SF | 2nd&6 | SF36 | Alex Smith incomplete pass to the left intended for Mario Manningham. | | |
| SF | 3rd&6 | SF36 | Alex Smith pass to the left to Michael Crabtree for 12 yards to the SF48. Tackled by Quinton Pointer. | | |
| SF | 1st&10 | SF48 | Frank Gore rush to the left for 1 yard to the SF49. Tackled by Rocky McIntosh. | | |
| SF | 2nd&9 | SF49 | Frank Gore rush to the left for 7 yards to the StL44. Tackled by Chris Long and William Hayes. | | |
| SF | 3rd&2 | StL44 | Frank Gore rush up the middle for a loss of 1 yard to the StL45. Tackled by Jermelle Cudjo and Quintin Mikell. | | |
| SF | 4th&3 | StL45 | Andy Lee punts for 38 yards to StL7. No return. | | |
| Team | Down | Spot | Play | StL | SF |
| StL | 1st&10 | StL7 | Steven Jackson rush up the middle for 7 yards to the StL14. Tackled by NaVorro Bowman and Justin Smith. | | |
| StL | 2nd&3 | StL14 | Steven Jackson rush to the left for 5 yards to the StL19. Tackled by NaVorro Bowman. | | |
| StL | 1st&10 | StL19 | Sam Bradford pass to the left to Lance Kendricks for 17 yards to the StL36. Tackled by Dashon Goldson. | | |
| StL | 1st&10 | StL36 | Penalty: Illegal Formation on St. Louis (Rodger Saffold) -5 yards. | | |
| StL | 1st&15 | StL31 | Daryl Richardson rush to the right for 32 yards to the SF37. Tackled by Aldon Smith. Penalty: Face Mask on San Francisco (Ray McDonald) 15 yards. | | |
| StL | 1st&10 | SF22 | Steven Jackson rush to the right for 2 yards to the SF20. Tackled by Ray McDonald. | | |
| StL | 2nd&8 | SF20 | Sam Bradford pass to the left to Danny Amendola for 13 yards to the SF7. Tackled by Tarell Brown. | | |
| StL | 1st&7 | SF7 | Steven Jackson rush to the right for 7 yards for a TOUCHDOWN. | | |
| StL | | | Greg Zuerlein extra point is good. | | |
| StL | | | Drive Stats: 7 plays, 93 yards, 4min 9sec | 14 | 0 |
| Team | Down | Spot | Play | StL | SF |
| StL | | | Greg Zuerlein kicks off to the SF0. Ted Ginn Jr. return for 23 yards to SF22. Tackled by Bradley Fletcher. FUMBLE, recovered by SF. | | |
| SF | 1st&10 | SF22 | Alex Smith rush to the left for 4 yards to the SF26. Tackled by Jo-Lonn Dunbar. | | |
| SF | 2nd&6 | SF26 | Alex Smith pass to the right to Vernon Davis for 6 yards to the SF32. Tackled by Quintin Mikell. | | |
| SF | 1st&10 | SF32 | Frank Gore rush to the left for 11 yards to the SF43. Tackled by Mario Haggan. | | |
| |
| Second Quarter |
| Team | Down | Spot | Play | StL | SF |
| SF | 1st&10 | SF43 | Alex Smith sacked at SF36 for a loss of 7 yards by Michael Brockers. | | |
| SF | 2nd&17 | SF36 | Frank Gore rush up the middle for 2 yards to the SF38. Tackled by James Laurinaitis and Kendall Langford. | | |
| SF | 3rd&15 | SF38 | Alex Smith pass to the middle to Michael Crabtree for 14 yards to the StL48. Tackled by Craig Dahl and Cortland Finnegan. | | |
| SF | 4th&1 | StL48 | Alex Smith rush up the middle for 1 yard to the StL47. Tackled by Kendall Langford. | | |
| SF | 1st&10 | StL47 | Alex Smith pass to the left to Michael Crabtree for 19 yards to the StL28. Tackled by Quintin Mikell. | | |
| SF | 1st&10 | StL28 | Frank Gore rush up the middle for 11 yards to the StL17. Tackled by Craig Dahl. | | |
| SF | 1st&10 | StL17 | Alex Smith pass to the left to Frank Gore for 3 yards to the StL14. Tackled by Mario Haggan. | | |
| SF | 2nd&7 | StL14 | Kendall Hunter rush to the left for 5 yards to the StL9. Tackled by William Hayes. | | |
| SF | 3rd&2 | StL9 | Penalty: Illegal Formation on San Francisco (Kyle Williams) -5 yards. | | |
| SF | 3rd&7 | StL14 | Alex Smith pass to the right to Michael Crabtree for 14 yards for a TOUCHDOWN. | | |
| SF | | | David Akers extra point is good. | | |
| SF | | | Drive Stats: 12 plays, 78 yards, 8min 34sec | 14 | 7 |
| Team | Down | Spot | Play | StL | SF |
| SF | | | David Akers kicks off to the StL5. Isaiah Pead return for 10 yards to StL15. Tackled by Bruce Miller. | | |
| StL | 1st&10 | StL15 | Steven Jackson rush to the right for 2 yards to the StL17. Tackled by Carlos Rogers. | | |
| StL | 2nd&8 | StL17 | Steven Jackson rush up the middle for 6 yards to the StL23. Tackled by NaVorro Bowman. | | |
| StL | 3rd&2 | StL23 | Sam Bradford incomplete pass to the right intended for Brandon Gibson defensed by Dashon Goldson. | | |
| StL | 4th&2 | StL23 | Johnny Hekker punts for 44 yards to SF33. Ted Ginn Jr. return for 11 yards to SF44. Tackled by Rodney McLeod. Penalty: Holding on San Francisco (Chris Culliver) -10 yards. | | |
| Team | Down | Spot | Play | StL | SF |
| SF | 1st&10 | SF34 | Colin Kaepernick rush to the left for 10 yards to the SF44. Tackled by Jo-Lonn Dunbar. | | |
| SF | 1st&10 | SF44 | Frank Gore rush to the right for 6 yards to the SF50. Tackled by Kendall Langford. | | |
| SF | 2nd&4 | SF50 | Frank Gore rush to the left for 7 yards to the StL43. Tackled by Jermelle Cudjo. | | |
| SF | 1st&10 | StL43 | Colin Kaepernick incomplete pass to the left intended for Vernon Davis. | | |
| SF | 2nd&10 | StL43 | Frank Gore rush up the middle for no gain to the StL43. Tackled by Cortland Finnegan. | | |
| SF | 3rd&10 | StL43 | Penalty: Holding on San Francisco (Jonathan Goodwin) -10 yards. | | |
| SF | 3rd&20 | SF47 | Colin Kaepernick rush to the left for 4 yards to the StL49. Tackled by Jo-Lonn Dunbar. | | |
| SF | 4th&16 | StL49 | Andy Lee punts for 49 yards to StL0. Touchback. | | |
| Team | Down | Spot | Play | StL | SF |
| StL | 1st&10 | StL20 | Sam Bradford incomplete pass to the right intended for Brandon Gibson. | | |
| StL | 2nd&10 | StL20 | Sam Bradford incomplete pass to the right intended for Daryl Richardson. | | |
| StL | 3rd&10 | StL20 | Penalty: False Start on St. Louis (Barry Richardson) -5 yards. | | |
| StL | 3rd&15 | StL15 | Sam Bradford pass to the right to Lance Kendricks for 12 yards to the StL27. Tackled by NaVorro Bowman. | | |
| StL | 4th&3 | StL27 | San Francisco 49ers timeout. | | |
| StL | 4th&3 | StL27 | Johnny Hekker punts for 13 yards to StL40. No return. | | |
| Team | Down | Spot | Play | StL | SF |
| SF | 1st&10 | StL40 | Colin Kaepernick incomplete pass to the left intended for Frank Gore. | | |
| SF | 2nd&10 | StL40 | Colin Kaepernick pass to the middle to Vernon Davis for 3 yards to the StL37. Tackled by James Laurinaitis. | | |
| SF | 3rd&7 | StL37 | Two Minute Warning. | | |
| SF | 3rd&7 | StL37 | Colin Kaepernick incomplete pass to the right intended for Michael Crabtree defensed by Bradley Fletcher. | | |
| SF | 4th&7 | StL37 | Andy Lee punts for 33 yards to StL4. No return. | | |
| Team | Down | Spot | Play | StL | SF |
| StL | 1st&10 | StL4 | Steven Jackson rush to the right for 1 yard to the StL5. Tackled by Isaac Sopoaga and NaVorro Bowman. | | |
| StL | 2nd&9 | StL5 | Steven Jackson rush to the left for 3 yards to the StL8. Tackled by Justin Smith. | | |
| StL | 3rd&6 | StL8 | San Francisco 49ers timeout. | | |
| StL | 3rd&6 | StL8 | Daryl Richardson rush to the right for 2 yards to the StL10. Tackled by Ahmad Brooks and Justin Smith. | | |
| StL | 4th&4 | StL10 | San Francisco 49ers timeout. | | |
| StL | 4th&4 | StL10 | Johnny Hekker pass to the right to Rodney McLeod for 21 yards to the StL31. Tackled by Perrish Cox. | | |
| StL | 1st&10 | StL31 | Sam Bradford pass to the left to Steve Smith for 4 yards to the StL35. Tackled by Carlos Rogers. | | |
| StL | 2nd&6 | StL35 | St. Louis Rams timeout. | | |
| StL | 2nd&6 | StL35 | Sam Bradford incomplete pass to the right intended for Lance Kendricks. | | |
| StL | 3rd&6 | StL35 | Sam Bradford sacked at StL27 for a loss of 8 yards by Aldon Smith. | | |
| Team | Down | Spot | Play | StL | SF |
| |
| Third Quarter |
| Team | Down | Spot | Play | StL | SF |
| SF | | | David Akers kicks off to the StL0. Touchback. | | |
| StL | 1st&10 | StL20 | Steven Jackson rush to the right for 3 yards to the StL23. Tackled by Patrick Willis. | | |
| StL | 2nd&7 | StL23 | Sam Bradford pass to the left to Danny Amendola for 2 yards to the StL25. Tackled by Carlos Rogers. | | |
| StL | 3rd&5 | StL25 | Sam Bradford pass to the right to Danny Amendola for 14 yards to the StL39. Tackled by Carlos Rogers. | | |
| StL | 1st&10 | StL39 | Steven Jackson rush up the middle for 6 yards to the StL45. Tackled by Isaac Sopoaga. | | |
| StL | 2nd&4 | StL45 | Steven Jackson rush to the right for 3 yards to the StL48. Tackled by NaVorro Bowman. | | |
| StL | 3rd&1 | StL48 | Sam Bradford rush up the middle for no gain to the StL48. FUMBLE, recovered by StL (Brit Miller). | | |
| StL | 4th&2 | StL47 | Johnny Hekker punts for 45 yards to SF8. No return. | | |
| Team | Down | Spot | Play | StL | SF |
| SF | 1st&10 | SF8 | Colin Kaepernick pass to the right to Kyle Williams for 11 yards to the SF19. Tackled by Quintin Mikell. FUMBLE, recovered by SF (Kyle Williams). | | |
| SF | 1st&10 | SF19 | Frank Gore rush to the right for 1 yard to the SF20. Tackled by Chris Long. | | |
| SF | 2nd&9 | SF20 | Colin Kaepernick incomplete pass to the right intended for Delanie Walker. | | |
| SF | 3rd&9 | SF20 | Colin Kaepernick incomplete pass to the left intended for Mario Manningham. | | |
| SF | 4th&9 | SF20 | Andy Lee punts for 44 yards to StL36. Danny Amendola return for 5 yards to StL41. Tackled by Dashon Goldson. Penalty: Illegal Block on St. Louis (Justin Cole) -10 yards. | | |
| Team | Down | Spot | Play | StL | SF |
| StL | 1st&10 | StL31 | Sam Bradford incomplete pass to the left intended for Danny Amendola defensed by Tarell Brown. | | |
| StL | 2nd&10 | StL31 | Sam Bradford pass to the right to Austin Pettis for 8 yards to the StL39. Tackled by Carlos Rogers. | | |
| StL | 3rd&2 | StL39 | Penalty: Delay of Game on St. Louis (Sam Bradford) -5 yards. | | |
| StL | 3rd&7 | StL34 | Sam Bradford pass to the left to Steve Smith for 7 yards to the StL41. Tackled by Donte Whitner. | | |
| StL | 1st&10 | StL41 | Steven Jackson rush to the right for 1 yard to the StL42. Tackled by Aldon Smith. | | |
| StL | 2nd&9 | StL42 | Sam Bradford incomplete pass to the right intended for Lance Kendricks defensed by Ahmad Brooks. | | |
| StL | 3rd&9 | StL42 | Penalty: False Start on St. Louis (Shelley Smith) -5 yards. | | |
| StL | 3rd&14 | StL37 | Sam Bradford pass to the right to Steven Jackson for 14 yards to the SF49. Tackled by Patrick Willis and Chris Culliver. | | |
| StL | 1st&10 | SF49 | Daryl Richardson rush to the left for 7 yards to the SF42. Tackled by Dashon Goldson. Penalty: Unsports. Conduct on San Francisco (Dashon Goldson) 15 yards. | | |
| StL | 1st&10 | SF27 | Daryl Richardson rush up the middle for 5 yards to the SF22. Tackled by Dashon Goldson. Penalty: Holding on St. Louis (Barry Richardson) -10 yards. | | |
| StL | 1st&15 | SF32 | Steven Jackson rush up the middle for 4 yards to the SF28. Tackled by NaVorro Bowman. | | |
| StL | 2nd&11 | SF28 | Sam Bradford pass to the left to Danny Amendola for 15 yards to the SF13. Tackled by NaVorro Bowman. | | |
| StL | 1st&10 | SF13 | Steven Jackson rush to the right for no gain to the SF13. Tackled by Ahmad Brooks and Patrick Willis. | | |
| StL | 2nd&10 | SF13 | Sam Bradford incomplete pass to the right intended for Steven Jackson. | | |
| StL | 3rd&10 | SF13 | Penalty: Roughing Passer on San Francisco (Ray McDonald) 6 yards. | | |
| StL | 1st&7 | SF7 | Steven Jackson rush to the right for 2 yards to the SF5. Tackled by Justin Smith and NaVorro Bowman. | | |
| StL | 2nd&5 | SF5 | Steven Jackson rush to the left for a loss of 4 yards to the SF9. Tackled by Aldon Smith. | | |
| StL | 3rd&9 | SF9 | Sam Bradford incomplete pass to the left intended for Lance Kendricks. | | |
| StL | 4th&9 | SF9 | Greg Zuerlein 27 yard field goal attempt is GOOD. Holder: Johnny Hekker. | | |
| StL | | | Drive Stats: 16 plays, 60 yards, 8min 25sec | 17 | 7 |
| Team | Down | Spot | Play | StL | SF |
| StL | | | Greg Zuerlein kicks off to the SF0. Ted Ginn Jr. return for 20 yards to SF19. Tackled by Rodney McLeod. | | |
| SF | 1st&10 | SF19 | Colin Kaepernick pass to the right to Randy Moss for 6 yards to the SF25. Tackled by Jo-Lonn Dunbar. | | |
| |
| Fourth Quarter |
| Team | Down | Spot | Play | StL | SF |
| SF | 2nd&4 | SF25 | Colin Kaepernick pass to the left to Mario Manningham for 20 yards to the SF45. Tackled by Trumaine Johnson. | | |
| SF | 1st&10 | SF45 | Colin Kaepernick sacked at SF45 for no gain by Robert Quinn. | | |
| SF | 2nd&10 | SF45 | Colin Kaepernick rush up the middle for no gain to the SF45. FUMBLE, recovered by SF (Frank Gore) and advanced for 12 yards. | | |
| SF | 1st&10 | StL43 | Colin Kaepernick pass to the left to Randy Moss for 13 yards to the StL30. Tackled by Trumaine Johnson. | | |
| SF | 1st&10 | StL30 | Frank Gore rush to the right for 6 yards to the StL24. Tackled by Quintin Mikell. | | |
| SF | 2nd&4 | StL24 | Colin Kaepernick sacked at StL38 for a loss of 14 yards by Mario Haggan. FUMBLE, recovered by SF (Bruce Miller). | | |
| SF | 3rd&18 | StL38 | Colin Kaepernick pass to the middle to Vernon Davis for 17 yards to the StL21. Tackled by Quintin Mikell. | | |
| SF | 4th&1 | StL21 | San Francisco 49ers timeout. | | |
| SF | 4th&1 | StL21 | Frank Gore rush to the right for 3 yards to the StL18. Tackled by Cortland Finnegan. | | |
| SF | 1st&10 | StL18 | Colin Kaepernick pass to the middle to Frank Gore for 11 yards to the StL7. Tackled by Michael Brockers. | | |
| SF | 1st&7 | StL7 | Colin Kaepernick rush to the right for 7 yards for a TOUCHDOWN. | | |
| SF | | | David Akers extra point is good. | | |
| SF | | | Drive Stats: 11 plays, 81 yards, 6min 38sec | 17 | 14 |
| Team | Down | Spot | Play | StL | SF |
| SF | | | David Akers kicks off to the StL0. Isaiah Pead return for 31 yards to StL28. Tackled by Tramaine Brock. FUMBLE, recovered by SF (Darcel McBath) and returned for 8 yards. Tackled by Jermelle Cudjo. | | |
| SF | 1st&10 | StL20 | Frank Gore rush to the right for 20 yards for a TOUCHDOWN. | | |
| SF | | | David Akers extra point is good. | | |
| SF | | | Drive Stats: 1 plays, 20 yards, 6sec | 17 | 21 |
| Team | Down | Spot | Play | StL | SF |
| SF | | | David Akers kicks off to the StL1. Isaiah Pead return for 18 yards to StL19. Tackled by Darcel McBath. | | |
| StL | 1st&10 | StL19 | Daryl Richardson rush to the left for 5 yards to the StL24. Tackled by NaVorro Bowman. | | |
| StL | 2nd&5 | StL24 | Sam Bradford pass to the left to Danny Amendola for 7 yards to the StL31. Tackled by Carlos Rogers. | | |
| StL | 1st&10 | StL31 | Sam Bradford pass to the left to Daryl Richardson for no gain to the StL31. Tackled by Patrick Willis. | | |
| StL | 2nd&10 | StL31 | Steven Jackson rush to the right for 2 yards to the StL33. Tackled by Ahmad Brooks and Justin Smith. | | |
| StL | 3rd&8 | StL33 | Sam Bradford incomplete pass to the right intended for Brandon Gibson. | | |
| StL | 4th&8 | StL33 | Johnny Hekker pass to the left to Lance Kendricks for 19 yards to the SF48. Tackled by Perrish Cox. | | |
| StL | 1st&10 | SF48 | Penalty: Holding on St. Louis (Robert Turner) -10 yards. | | |
| StL | 1st&20 | StL42 | Steven Jackson rush to the right for 7 yards to the StL49. Tackled by Ahmad Brooks and Justin Smith. | | |
| StL | 2nd&13 | StL49 | Sam Bradford pass to the middle to Danny Amendola for 5 yards to the SF46. Tackled by Perrish Cox. | | |
| StL | 3rd&8 | SF46 | Sam Bradford pass to the middle to Danny Amendola for 16 yards to the SF30. Tackled by Patrick Willis and Dashon Goldson. | | |
| StL | 1st&10 | SF30 | Steven Jackson rush to the left for 2 yards to the SF28. Tackled by Demarcus Dobbs. | | |
| StL | 2nd&8 | SF28 | Sam Bradford pass to the left to Brandon Gibson for 14 yards to the SF14. | | |
| StL | 1st&10 | SF14 | Two Minute Warning. | | |
| StL | 1st&10 | SF14 | Steven Jackson rush to the left for 4 yards to the SF10. Tackled by Dashon Goldson. | | |
| StL | 2nd&6 | SF10 | Sam Bradford pass to the right to Danny Amendola for 8 yards to the SF2. Tackled by Donte Whitner. | | |
| StL | 1st&2 | SF2 | St. Louis Rams timeout. | | |
| StL | 1st&2 | SF2 | Sam Bradford pass to the right to Austin Pettis for 2 yards for a TOUCHDOWN. | | |
| StL | | | Greg Zuerlein extra point is good. | | |
| StL | | | Drive Stats: 14 plays, 81 yards, 7min 14sec | 24 | 21 |
| Team | Down | Spot | Play | StL | SF |
| StL | | | Greg Zuerlein kicks off to the SF0. Ted Ginn Jr. return for 25 yards to SF22. Tackled by Quintin Mikell. | | |
| SF | 1st&10 | SF22 | Colin Kaepernick rush to the left for 19 yards to the SF41. | | |
| SF | 1st&10 | SF41 | Colin Kaepernick pass to the left to Vernon Davis for 4 yards to the SF45. Tackled by Trumaine Johnson. | | |
| SF | 2nd&6 | SF45 | St. Louis Rams timeout. | | |
| SF | 2nd&6 | SF45 | Colin Kaepernick rush to the left for 10 yards to the StL45. | | |
| SF | 1st&10 | StL45 | Colin Kaepernick pass to the right to Kyle Williams for 13 yards to the StL32. | | |
| SF | 1st&10 | StL32 | Frank Gore rush up the middle for 9 yards to the StL23. Tackled by Quintin Mikell and James Laurinaitis. | | |
| SF | 2nd&1 | StL23 | San Francisco 49ers timeout. | | |
| SF | 2nd&1 | StL23 | Colin Kaepernick pass to the right to Kendall Hunter for 8 yards to the StL15. Tackled by Jo-Lonn Dunbar and Cortland Finnegan. | | |
| SF | 1st&10 | StL15 | San Francisco 49ers timeout. | | |
| SF | 1st&10 | StL15 | Colin Kaepernick incomplete pass to the right intended for Kyle Williams. | | |
| SF | 2nd&10 | StL15 | David Akers 33 yard field goal attempt is GOOD. Holder: Andy Lee. | | |
| SF | | | Drive Stats: 8 plays, 63 yards, 1min 6sec | 24 | 24 |
| Team | Down | Spot | Play | StL | SF |
| SF | | | David Akers kicks off to the StL20. Danny Amendola return for 4 yards to StL24. Tackled by C.J. Spillman. | | |
| Team | Down | Spot | Play | StL | SF |
| |
| Overtime |
| Team | Down | Spot | Play | StL | SF |
| SF | | | David Akers kicks off to the StL0. Isaiah Pead return for 21 yards to StL18. Tackled by Bruce Miller. | | |
| StL | 1st&10 | StL18 | Penalty: Illegal Formation on St. Louis (Rodger Saffold) -5 yards. | | |
| StL | 1st&15 | StL13 | Steven Jackson rush up the middle for 2 yards to the StL15. Tackled by Aldon Smith. | | |
| StL | 2nd&13 | StL15 | Sam Bradford pass to the middle to Steven Jackson for 12 yards to the StL27. Tackled by Patrick Willis. | | |
| StL | 3rd&1 | StL27 | Sam Bradford incomplete pass to the right intended for Brit Miller defensed by Ahmad Brooks. | | |
| StL | 4th&1 | StL27 | Johnny Hekker punts for 45 yards to SF28. Ted Ginn Jr. return for 12 yards to SF40. Tackled by Craig Dahl. | | |
| Team | Down | Spot | Play | StL | SF |
| SF | 1st&10 | SF40 | San Francisco 49ers timeout. | | |
| SF | 1st&10 | SF40 | Colin Kaepernick pass to the right to Michael Crabtree for 11 yards to the StL49. Tackled by Cortland Finnegan. | | |
| SF | 1st&10 | StL49 | Kendall Hunter rush to the left for 6 yards to the StL43. Tackled by James Laurinaitis and Quintin Mikell. | | |
| SF | 2nd&4 | StL43 | Frank Gore rush to the left for 4 yards to the StL39. Tackled by Michael Brockers. | | |
| SF | 1st&10 | StL39 | Colin Kaepernick rush to the right for 14 yards to the StL25. Tackled by Craig Dahl. | | |
| SF | 1st&10 | StL25 | Frank Gore rush up the middle for 1 yard to the StL24. Tackled by Jermelle Cudjo. | | |
| SF | 2nd&9 | StL24 | Frank Gore rush to the left for a loss of 3 yards to the StL27. Tackled by Mario Haggan. | | |
| SF | 3rd&12 | StL27 | San Francisco 49ers timeout. | | |
| SF | 3rd&12 | StL27 | Frank Gore rush to the right for 4 yards to the StL23. Tackled by Mario Haggan. | | |
| SF | 4th&8 | StL23 | 41 yard field goal attempt by David Akers is NO GOOD. Holder: Andy Lee. | | |
| Team | Down | Spot | Play | StL | SF |
| StL | 1st&10 | StL31 | Daryl Richardson rush to the left for 3 yards to the StL34. Tackled by Justin Smith. | | |
| StL | 2nd&7 | StL34 | Sam Bradford pass to the right to Brandon Gibson for 9 yards to the StL43. Tackled by Dashon Goldson. | | |
| StL | 1st&10 | StL43 | Steven Jackson rush up the middle for 7 yards to the StL50. Tackled by NaVorro Bowman. | | |
| StL | 2nd&3 | StL50 | Steven Jackson rush to the right for a loss of 1 yard to the StL49. Tackled by Ahmad Brooks and NaVorro Bowman. | | |
| StL | 3rd&4 | StL49 | Sam Bradford pass to the middle to Danny Amendola for 10 yards to the SF41. Tackled by Tarell Brown. | | |
| StL | 1st&10 | SF41 | Steven Jackson rush up the middle for 8 yards to the SF33. Tackled by Donte Whitner. | | |
| StL | 2nd&2 | SF33 | Penalty: Illegal Shift on St. Louis (Brit Miller) -5 yards. | | |
| StL | 2nd&7 | SF38 | Daryl Richardson rush to the left for 4 yards to the SF34. Tackled by Patrick Willis. | | |
| StL | 3rd&3 | SF34 | St. Louis Rams timeout. | | |
| StL | 3rd&3 | SF34 | Steven Jackson rush to the right for a loss of 1 yard to the SF35. Tackled by Justin Smith. | | |
| StL | 4th&4 | SF35 | Penalty: Delay of Game on St. Louis (Johnny Hekker) -5 yards. | | |
| StL | 4th&9 | SF40 | 58 yard field goal attempt by Greg Zuerlein is NO GOOD. Holder: Johnny Hekker. | | |
| SF | 1st&10 | SF48 | Colin Kaepernick rush to the right for 2 yards to the SF50. Tackled by Robert Quinn. | | |
| SF | 2nd&8 | SF50 | Frank Gore rush up the middle for 1 yard to the StL49. Tackled by James Laurinaitis. | | |
| SF | 3rd&7 | StL49 | Two Minute Warning. | | |
| SF | 3rd&7 | StL49 | Colin Kaepernick sacked at SF43 for a loss of 8 yards by Chris Long. | | |
| SF | 4th&15 | SF43 | St. Louis Rams timeout. | | |
| SF | 4th&15 | SF43 | Andy Lee punts for 46 yards to StL11. Danny Amendola return for 3 yards to StL14. Tackled by Demarcus Dobbs. | | |
| Team | Down | Spot | Play | StL | SF |
| StL | 1st&10 | StL14 | Sam Bradford pass to the right to Austin Pettis for 5 yards to the StL19. Tackled by Chris Culliver. | | |
| StL | 2nd&5 | StL19 | Sam Bradford incomplete pass to the right intended for Austin Pettis defensed by Ahmad Brooks. | | |
| StL | 3rd&5 | StL19 | Penalty: Holding on San Francisco (Patrick Willis) 5 yards. | | |
| StL | 1st&10 | StL24 | Sam Bradford pass to the left to Isaiah Pead for 9 yards to the StL33. Tackled by Ahmad Brooks. FUMBLE, recovered by StL (Robert Turner). | | |
| StL | 2nd&1 | StL33 | Sam Bradford incomplete pass to the middle. | | |
| StL | 3rd&1 | StL33 | Sam Bradford pass to the right to Danny Amendola for 5 yards to the StL38. Tackled by Dashon Goldson. | | |
| StL | 1st&10 | StL38 | Sam Bradford sacked at StL30 for a loss of 8 yards by Aldon Smith. | | |
| StL | 2nd&18 | StL30 | Sam Bradford incomplete pass to the middle. | | |
| StL | 3rd&18 | StL30 | Penalty: Delay of Game on St. Louis (Sam Bradford) -5 yards. | | |
| StL | 3rd&23 | StL25 | Sam Bradford pass to the left to Brandon Gibson for 24 yards to the StL49. Tackled by C.J. Spillman. | | |