| First Quarter |
| Team | Down | Spot | Play | Chi | SF |
| Chi | | | Robbie Gould kicks off to the SF0. Ted Ginn Jr. return for 19 yards to SF18. Tackled by Geno Hayes. | | |
| SF | 1st&10 | SF18 | Colin Kaepernick pass to the left to Mario Manningham for 8 yards to the SF26. Penalty: Unnecessary Roughness on Chicago (Chris Conte) 15 yards. | | |
| SF | 1st&10 | SF41 | Frank Gore rush to the right for 1 yard to the SF42. Tackled by Tim Jennings. | | |
| SF | 2nd&9 | SF42 | Colin Kaepernick pass to the left to Vernon Davis for 22 yards to the Chi36. Tackled by Major Wright. | | |
| SF | 1st&10 | Chi36 | Frank Gore rush up the middle for 1 yard to the Chi35. Tackled by Julius Peppers and Brian Urlacher. | | |
| SF | 2nd&9 | Chi35 | Colin Kaepernick pass to the right to Vernon Davis for 12 yards to the Chi23. Tackled by Charles Tillman and Lance Briggs. | | |
| SF | 1st&10 | Chi23 | Kendall Hunter rush to the right for 6 yards to the Chi17. Tackled by Major Wright. | | |
| SF | 2nd&4 | Chi17 | Colin Kaepernick pass to the left to Kyle Williams for 3 yards to the Chi14. Tackled by Charles Tillman. | | |
| SF | 3rd&1 | Chi14 | Colin Kaepernick incomplete pass to the right intended for Vernon Davis. | | |
| SF | 4th&1 | Chi14 | David Akers 32 yard field goal attempt is GOOD. Holder: Andy Lee. | | |
| SF | | | Drive Stats: 9 plays, 68 yards, 4min 28sec | 0 | 3 |
| Team | Down | Spot | Play | Chi | SF |
| SF | | | David Akers kicks off to the Chi0. Touchback. | | |
| Chi | 1st&10 | Chi20 | Matt Forte rush to the left for 4 yards to the Chi24. Tackled by NaVorro Bowman. | | |
| Chi | 2nd&6 | Chi24 | Matt Forte rush to the right for 4 yards to the Chi28. Tackled by Ray McDonald. | | |
| Chi | 3rd&2 | Chi28 | Jason Campbell sacked at Chi18 for a loss of 10 yards by Aldon Smith. | | |
| Chi | 4th&12 | Chi18 | Adam Podlesh punts for 37 yards to SF45. Ted Ginn Jr. return for 2 yards to SF47. Tackled by Zack Bowman. Penalty: Holding on San Francisco (Demarcus Dobbs) -10 yards. | | |
| Team | Down | Spot | Play | Chi | SF |
| SF | 1st&10 | SF37 | Colin Kaepernick pass to the left to Delanie Walker for 9 yards to the SF46. Tackled by Major Wright. | | |
| SF | 2nd&1 | SF46 | Frank Gore rush up the middle for a loss of 6 yards to the SF40. Tackled by Stephen Paea and Brian Urlacher. | | |
| SF | 3rd&7 | SF40 | Colin Kaepernick pass to the right to Kyle Williams for 57 yards to the Chi3. Tackled by Chris Conte. | | |
| SF | 1st&3 | Chi3 | Colin Kaepernick pass to the right to Vernon Davis for 3 yards for a TOUCHDOWN. | | |
| SF | | | David Akers extra point is good. | | |
| SF | | | Drive Stats: 4 plays, 63 yards, 2min 16sec | 0 | 10 |
| Team | Down | Spot | Play | Chi | SF |
| SF | | | David Akers kicks off to the Chi0. Devin Hester return for 22 yards to Chi19. Tackled by Tavares Gooden. | | |
| Chi | 1st&10 | Chi19 | Matt Forte rush to the right for 7 yards to the Chi26. Tackled by Patrick Willis. | | |
| Chi | 2nd&3 | Chi26 | Matt Forte rush to the right for 4 yards to the Chi30. Tackled by Patrick Willis. | | |
| Chi | 1st&10 | Chi30 | Jason Campbell pass to the left to Alshon Jeffery for 9 yards to the Chi39. Tackled by Tarell Brown. | | |
| Chi | 2nd&1 | Chi39 | Matt Forte rush up the middle for no gain to the Chi39. Tackled by Isaac Sopoaga. | | |
| Chi | 3rd&1 | Chi39 | Matt Forte rush to the right for 3 yards to the Chi42. Tackled by NaVorro Bowman. | | |
| Chi | 1st&10 | Chi42 | Jason Campbell incomplete pass to the left intended for Evan Rodriguez defensed by Patrick Willis. | | |
| Chi | 2nd&10 | Chi42 | Michael Bush rush to the right for 1 yard to the Chi43. Tackled by Ray McDonald and Justin Smith. | | |
| Chi | 3rd&9 | Chi43 | Jason Campbell incomplete pass to the right intended for Matt Forte defensed by Patrick Willis. | | |
| Chi | 4th&9 | Chi43 | Adam Podlesh punts for 53 yards to SF4. No return. | | |
| Team | Down | Spot | Play | Chi | SF |
| SF | 1st&10 | SF4 | Frank Gore rush to the right for 13 yards to the SF17. Tackled by Chris Conte. | | |
| SF | 1st&10 | SF17 | Colin Kaepernick pass to the left to Randy Moss for 12 yards to the SF29. Tackled by Charles Tillman. | | |
| SF | 1st&10 | SF29 | Frank Gore rush to the left for 7 yards to the SF36. Tackled by Julius Peppers. | | |
| |
| Second Quarter |
| Team | Down | Spot | Play | Chi | SF |
| SF | 2nd&3 | SF36 | Colin Kaepernick pass to the left to Vernon Davis for 32 yards to the Chi32. Tackled by Chris Conte. | | |
| SF | 1st&10 | Chi32 | Frank Gore rush to the right for 13 yards to the Chi19. Tackled by Major Wright. | | |
| SF | 1st&10 | Chi19 | Colin Kaepernick incomplete pass to the left intended for Randy Moss. | | |
| SF | 2nd&10 | Chi19 | Penalty: Holding on Chicago (Major Wright) 5 yards. | | |
| SF | 1st&10 | Chi14 | Frank Gore rush to the right for no gain to the Chi14. Tackled by Tim Jennings. | | |
| SF | 2nd&10 | Chi14 | Kendall Hunter rush up the middle for 14 yards for a TOUCHDOWN. | | |
| SF | | | Penalty: False Start on San Francisco (Mike Iupati) -5 yards. | | |
| SF | | | David Akers extra point is good. | | |
| SF | | | Drive Stats: 8 plays, 96 yards, 4min 0sec | 0 | 17 |
| Team | Down | Spot | Play | Chi | SF |
| SF | | | David Akers kicks off to the Chi0. Devin Hester return for 26 yards to Chi26. Tackled by Perrish Cox. Penalty: Unnecessary Roughness on San Francisco (C.J. Spillman) 15 yards. | | |
| Chi | 1st&10 | Chi41 | Jason Campbell sacked at Chi35 for a loss of 6 yards by Aldon Smith. FUMBLE, recovered by Chi (Jason Campbell). | | |
| Chi | 2nd&16 | Chi35 | Matt Forte rush to the left for 4 yards to the Chi39. Tackled by NaVorro Bowman. | | |
| Chi | 3rd&12 | Chi39 | Jason Campbell pass intended for Devin Hester INTERCEPTED by Tarell Brown and returned for 5 yards. Tackled by Devin Hester. | | |
| Team | Down | Spot | Play | Chi | SF |
| SF | 1st&10 | Chi44 | Frank Gore rush up the middle for 14 yards to the Chi30. Tackled by Chris Conte. | | |
| SF | 1st&10 | Chi30 | Frank Gore rush up the middle for 3 yards to the Chi27. Tackled by Tim Jennings and Stephen Paea. | | |
| SF | 2nd&7 | Chi27 | Kendall Hunter sacked at Chi31 for a loss of 4 yards by Nick Roach and Lance Briggs. | | |
| SF | 3rd&11 | Chi31 | Chicago Bears timeout. | | |
| SF | 3rd&11 | Chi31 | Colin Kaepernick pass to the right to Michael Crabtree for 20 yards to the Chi11. Tackled by Tim Jennings. | | |
| SF | 1st&10 | Chi11 | Frank Gore rush to the right for a loss of 4 yards to the Chi15. Tackled by Brian Urlacher. | | |
| SF | 2nd&14 | Chi15 | San Francisco 49ers timeout. | | |
| SF | 2nd&14 | Chi15 | Colin Kaepernick rush to the right for 3 yards to the Chi12. Tackled by Brian Urlacher. | | |
| SF | 3rd&11 | Chi12 | Colin Kaepernick sacked at Chi19 for a loss of 7 yards by Israel Idonije and Corey Wootton. | | |
| SF | 4th&18 | Chi19 | David Akers 37 yard field goal attempt is GOOD. Holder: Andy Lee. | | |
| SF | | | Drive Stats: 8 plays, 25 yards, 4min 47sec | 0 | 20 |
| Team | Down | Spot | Play | Chi | SF |
| SF | | | David Akers kicks off to the Chi10. Devin Hester return for 21 yards to Chi31. Tackled by Bruce Miller and Delanie Walker. | | |
| Chi | 1st&10 | Chi31 | Matt Forte rush to the right for a loss of 1 yard to the Chi30. Tackled by Justin Smith. | | |
| Chi | 2nd&11 | Chi30 | Matt Forte rush up the middle for no gain to the Chi30. Tackled by Patrick Willis. | | |
| Chi | 3rd&11 | Chi30 | Jason Campbell pass to the right to Matt Forte for no gain to the Chi30. Tackled by Patrick Willis. | | |
| Chi | 4th&11 | Chi30 | Adam Podlesh punts for 48 yards to SF22. Ted Ginn Jr. return for 12 yards to SF34. Tackled by Anthony Walters. | | |
| Team | Down | Spot | Play | Chi | SF |
| SF | 1st&10 | SF34 | Colin Kaepernick pass to the right to Kendall Hunter for 3 yards to the SF37. Tackled by Charles Tillman. | | |
| SF | 2nd&7 | SF37 | Frank Gore rush to the left for 3 yards to the SF40. Tackled by Nick Roach. | | |
| SF | 3rd&4 | SF40 | Colin Kaepernick rush up the middle for 3 yards to the SF43. Tackled by Lance Briggs. | | |
| SF | 4th&1 | SF43 | Chicago Bears timeout. | | |
| SF | 4th&1 | SF43 | Andy Lee punts for 46 yards to Chi11. No return. | | |
| Team | Down | Spot | Play | Chi | SF |
| Chi | 1st&10 | Chi11 | Jason Campbell sacked at Chi5 for a loss of 6 yards by Aldon Smith. | | |
| Chi | 2nd&16 | Chi5 | Two Minute Warning. | | |
| Chi | 2nd&16 | Chi5 | Matt Forte rush to the left for 2 yards to the Chi7. Tackled by Ahmad Brooks. | | |
| Chi | 3rd&14 | Chi7 | San Francisco 49ers timeout. | | |
| Chi | 3rd&14 | Chi7 | Jason Campbell incomplete pass to the left intended for Brandon Marshall. | | |
| Chi | 4th&14 | Chi7 | Adam Podlesh punts for 53 yards to SF40. Ted Ginn Jr. return for 8 yards to SF48. Tackled by Craig Steltz. Penalty: Illegal Block on San Francisco (Anthony Dixon) -10 yards. | | |
| Team | Down | Spot | Play | Chi | SF |
| SF | 1st&10 | SF38 | Colin Kaepernick pass to the left to Vernon Davis for 3 yards to the SF41. Tackled by Lance Briggs. | | |
| SF | 2nd&7 | SF41 | Frank Gore rush up the middle for 5 yards to the SF46. Tackled by Kelvin Hayden. | | |
| SF | 3rd&2 | SF46 | Colin Kaepernick incomplete pass to the left intended for Michael Crabtree defensed by Charles Tillman. | | |
| SF | 4th&2 | SF46 | Andy Lee punts for 41 yards to Chi13. Devin Hester return for 4 yards to Chi17. Tackled by Dashon Goldson. Penalty: Holding on Chicago (Blake Costanzo) -10 yards. | | |
| Team | Down | Spot | Play | Chi | SF |
| Chi | 1st&10 | Chi7 | Jason Campbell pass to the middle to Earl Bennett for 6 yards to the Chi13. Tackled by NaVorro Bowman. | | |
| Chi | 2nd&4 | Chi13 | Jason Campbell pass to the left to Alshon Jeffery for 6 yards to the Chi19. | | |
| Chi | 1st&10 | Chi19 | Matt Forte rush up the middle for 8 yards to the Chi27. Tackled by NaVorro Bowman. | | |
| Team | Down | Spot | Play | Chi | SF |
| |
| Third Quarter |
| Team | Down | Spot | Play | Chi | SF |
| SF | | | David Akers kicks off to the Chi0. Touchback. | | |
| Chi | 1st&10 | Chi20 | Matt Forte rush up the middle for 3 yards to the Chi23. Tackled by Donte Whitner. | | |
| Chi | 2nd&7 | Chi23 | Matt Forte rush up the middle for 4 yards to the Chi27. Tackled by NaVorro Bowman and Justin Smith. | | |
| Chi | 3rd&3 | Chi27 | Jason Campbell sacked at Chi16 for a loss of 11 yards by Aldon Smith. | | |
| Chi | 4th&14 | Chi16 | Adam Podlesh punts for 43 yards to SF41. Ted Ginn Jr. return for a loss of 3 yards to SF38. Tackled by Zack Bowman. | | |
| Team | Down | Spot | Play | Chi | SF |
| SF | 1st&10 | SF38 | Frank Gore rush to the left for 11 yards to the SF49. Tackled by Nick Roach. | | |
| SF | 1st&10 | SF49 | Colin Kaepernick pass to the left to Mario Manningham for 37 yards to the Chi14. Tackled by Major Wright. | | |
| SF | 1st&10 | Chi14 | Frank Gore rush to the left for 4 yards to the Chi10. Tackled by Brian Urlacher. | | |
| SF | 2nd&6 | Chi10 | Colin Kaepernick incomplete pass to the left intended for Delanie Walker. | | |
| SF | 3rd&6 | Chi10 | Colin Kaepernick pass to the left to Michael Crabtree for 10 yards for a TOUCHDOWN. | | |
| SF | | | David Akers extra point is good. | | |
| SF | | | Drive Stats: 5 plays, 62 yards, 2min 8sec | 0 | 27 |
| Team | Down | Spot | Play | Chi | SF |
| SF | | | David Akers kicks off to the Chi0. Devin Hester return for 30 yards to Chi26. Tackled by Bruce Miller and Tramaine Brock. | | |
| Chi | 1st&10 | Chi26 | Jason Campbell pass to the left to Brandon Marshall for 8 yards to the Chi34. Tackled by Tarell Brown and Donte Whitner. | | |
| Chi | 2nd&2 | Chi34 | Michael Bush rush to the left for 6 yards to the Chi40. Tackled by Donte Whitner. | | |
| Chi | 1st&10 | Chi40 | Michael Bush rush to the right for 2 yards to the Chi42. Tackled by Ray McDonald. | | |
| Chi | 2nd&8 | Chi42 | Jason Campbell rush up the middle for 13 yards to the SF45. Tackled by Carlos Rogers. | | |
| Chi | 1st&10 | SF45 | Michael Bush rush to the right for no gain to the SF45. Tackled by Isaac Sopoaga. | | |
| Chi | 2nd&10 | SF45 | Jason Campbell pass to the right to Michael Bush for 18 yards to the SF27. Tackled by Donte Whitner and Tarell Brown. | | |
| Chi | 1st&10 | SF27 | Penalty: Holding on Chicago (Chilo Rachal) -10 yards. | | |
| Chi | 1st&20 | SF37 | Matt Forte rush to the left for 1 yard to the SF36. Tackled by NaVorro Bowman and Demarcus Dobbs. | | |
| Chi | 2nd&19 | SF36 | Jason Campbell incomplete pass to the left intended for Alshon Jeffery. | | |
| Chi | 3rd&19 | SF36 | Jason Campbell sacked at SF49 for a loss of 13 yards by Ahmad Brooks. | | |
| Chi | 3rd&- | SF49 | Penalty: Illegal Block on San Francisco (Aldon Smith) 10 yards. | | |
| Chi | 1st&10 | SF26 | Jason Campbell incomplete pass to the right intended for Alshon Jeffery. | | |
| Chi | 2nd&10 | SF26 | Matt Forte rush to the left for 3 yards to the SF23. Tackled by Dashon Goldson. | | |
| Chi | 3rd&7 | SF23 | Jason Campbell pass to the right to Kellen Davis for 9 yards to the SF14. Tackled by Carlos Rogers and NaVorro Bowman. | | |
| Chi | 1st&10 | SF14 | Matt Forte rush to the right for 1 yard to the SF13. Tackled by NaVorro Bowman. | | |
| Chi | 2nd&9 | SF13 | Jason Campbell pass to the right to Brandon Marshall for 13 yards for a TOUCHDOWN. | | |
| Chi | | | Robbie Gould extra point is good. | | |
| Chi | | | Drive Stats: 13 plays, 74 yards, 7min 22sec | 7 | 27 |
| Team | Down | Spot | Play | Chi | SF |
| Chi | | | Robbie Gould kicks off to the SF0. Ted Ginn Jr. return for 23 yards to SF16. Tackled by Geno Hayes. | | |
| SF | 1st&10 | SF16 | Kendall Hunter rush to the left for 8 yards to the SF24. Tackled by Major Wright. | | |
| SF | 2nd&2 | SF24 | Colin Kaepernick incomplete pass to the left intended for Vernon Davis. | | |
| SF | 3rd&2 | SF24 | Colin Kaepernick pass to the right to Michael Crabtree for 1 yard to the SF25. Tackled by Charles Tillman. | | |
| SF | 4th&1 | SF25 | Andy Lee punts for 47 yards to Chi28. Devin Hester return for a loss of 9 yards to Chi19. Tackled by Tramaine Brock and Anthony Dixon. | | |
| Team | Down | Spot | Play | Chi | SF |
| Chi | 1st&10 | Chi19 | Michael Bush rush up the middle for no gain to the Chi19. Tackled by NaVorro Bowman. | | |
| Chi | 2nd&10 | Chi19 | Jason Campbell pass to the left to Devin Hester for 7 yards to the Chi26. Tackled by NaVorro Bowman. | | |
| Chi | 3rd&3 | Chi26 | Jason Campbell pass intended for Earl Bennett INTERCEPTED by Dashon Goldson. No return. | | |
| Team | Down | Spot | Play | Chi | SF |
| SF | 1st&10 | Chi37 | Colin Kaepernick rush to the right for 5 yards to the Chi32. Tackled by Chris Conte. | | |
| |
| Fourth Quarter |
| Team | Down | Spot | Play | Chi | SF |
| SF | 2nd&5 | Chi32 | Frank Gore rush to the right for 1 yard to the Chi31. Tackled by Tim Jennings. | | |
| SF | 3rd&4 | Chi31 | Frank Gore rush up the middle for 8 yards to the Chi23. Tackled by Major Wright. | | |
| SF | 1st&10 | Chi23 | Colin Kaepernick incomplete pass to the right intended for Delanie Walker defensed by Nick Roach. | | |
| SF | 2nd&10 | Chi23 | Kendall Hunter rush to the right for a loss of 2 yards to the Chi25. Tackled by Lance Briggs and Brian Urlacher. | | |
| SF | 3rd&12 | Chi25 | Colin Kaepernick pass to the middle to Vernon Davis for 11 yards to the Chi14. Tackled by Major Wright. | | |
| SF | 4th&1 | Chi14 | San Francisco 49ers timeout. | | |
| SF | 4th&1 | Chi14 | David Akers 32 yard field goal attempt is GOOD. Holder: Andy Lee. | | |
| SF | | | Drive Stats: 7 plays, 23 yards, 3min 25sec | 7 | 30 |
| Team | Down | Spot | Play | Chi | SF |
| SF | | | David Akers kicks off to the Chi0. Devin Hester return for 27 yards to Chi24. Tackled by Chris Culliver. FUMBLE, recovered by Chi (Sherrick McManis). | | |
| Chi | 1st&10 | Chi26 | Chicago Bears timeout. | | |
| Chi | 1st&10 | Chi26 | Penalty: Holding on Chicago (Chilo Rachal) -10 yards. | | |
| Chi | 1st&20 | Chi16 | Jason Campbell pass to the right to Matt Forte for no gain to the Chi16. Tackled by Patrick Willis. | | |
| Chi | 2nd&20 | Chi16 | Jason Campbell sacked at Chi8 for a loss of 8 yards by Justin Smith and Aldon Smith. | | |
| Chi | 3rd&20 | SF0 | Chicago Bears timeout. | | |
| Chi | 3rd&28 | Chi8 | Jason Campbell sacked at Chi0 for a loss of 8 yards by Aldon Smith. FUMBLE, recovered by Chi (Chilo Rachal). Safety. | | |
| Team | Down | Spot | Play | Chi | SF |
| Chi | | | Adam Podlesh kicks off to the SF16. Ted Ginn Jr. return for 21 yards to SF37. Tackled by J.T. Thomas. | | |
| SF | 1st&10 | SF37 | Kendall Hunter rush to the left for 1 yard to the SF38. Tackled by Charles Tillman and Brian Urlacher. | | |
| SF | 2nd&9 | SF38 | Colin Kaepernick incomplete pass to the right intended for Michael Crabtree. | | |
| SF | 3rd&9 | SF38 | Frank Gore rush up the middle for 4 yards to the SF42. Tackled by Israel Idonije. | | |
| SF | 4th&5 | SF42 | Andy Lee punts for 54 yards to Chi4. Devin Hester return for 4 yards to Chi8. Tackled by NaVorro Bowman. | | |
| Team | Down | Spot | Play | Chi | SF |
| Chi | 1st&10 | Chi8 | Matt Forte rush up the middle for 2 yards to the Chi10. Tackled by Isaac Sopoaga and Patrick Willis. | | |
| Chi | 2nd&8 | Chi10 | Matt Forte rush to the right for 7 yards to the Chi17. Tackled by Carlos Rogers. | | |
| Chi | 3rd&1 | Chi17 | Matt Forte rush up the middle for 3 yards to the Chi20. Tackled by Clark Haggans. | | |
| Chi | 1st&10 | Chi20 | Jason Campbell pass to the left to Devin Hester for 7 yards to the Chi27. Tackled by Donte Whitner. | | |
| Chi | 2nd&3 | Chi27 | Matt Forte rush up the middle for 6 yards to the Chi33. Tackled by Ricky Jean Francois. | | |
| Chi | 1st&10 | Chi33 | Jason Campbell pass to the right to Devin Hester for 9 yards to the Chi42. Tackled by Chris Culliver. | | |
| Chi | 2nd&1 | Chi42 | Jason Campbell pass to the middle to Matt Forte for 4 yards to the Chi46. Tackled by NaVorro Bowman. | | |
| Chi | 1st&10 | Chi46 | Matt Forte rush to the left for a loss of 2 yards to the Chi44. Tackled by Ricky Jean Francois. | | |
| Chi | 2nd&12 | Chi44 | Jason Campbell incomplete pass to the left intended for Brandon Marshall. | | |
| Chi | 3rd&12 | Chi44 | Jason Campbell pass to the right to Kellen Davis for 11 yards to the SF45. Tackled by Patrick Willis. | | |
| Chi | 4th&1 | SF45 | Armando Allen rush up the middle for no gain to the SF45. Tackled by Demarcus Dobbs. | | |
| SF | 1st&10 | SF45 | Anthony Dixon rush to the left for 4 yards to the SF49. Tackled by Corey Wootton. | | |
| SF | 2nd&6 | SF49 | Two Minute Warning. | | |
| SF | 2nd&6 | SF49 | Anthony Dixon rush to the left for 1 yard to the SF50. Tackled by Amobi Okoye and Charles Tillman. | | |
| SF | 3rd&5 | SF50 | Anthony Dixon rush to the right for 1 yard to the Chi49. Tackled by Lance Briggs. | | |
| SF | 4th&4 | Chi49 | San Francisco 49ers timeout. | | |
| SF | 4th&4 | Chi49 | Penalty: Offside on Chicago (J.T. Thomas) 5 yards. | | |
| SF | 1st&10 | Chi44 | Colin Kaepernick rush up the middle for a loss of 1 yard to the Chi45. | | |