| First Quarter |
| Team | Down | Spot | Play | SF | StL |
| SF | | | David Akers kicks off to the StL0. Touchback. | | |
| StL | 1st&10 | StL20 | Sam Bradford incomplete pass to the right intended for Chris Givens defensed by Ahmad Brooks. | | |
| StL | 2nd&10 | StL20 | Steven Jackson rush to the left for 4 yards to the StL24. Tackled by Patrick Willis. Penalty: Unnecessary Roughness on San Francisco (NaVorro Bowman) 15 yards. | | |
| StL | 1st&10 | StL39 | Steven Jackson rush to the right for 3 yards to the StL42. Tackled by Justin Smith. | | |
| StL | 2nd&7 | StL42 | Steven Jackson rush to the right for 6 yards to the StL48. Tackled by Donte Whitner. | | |
| StL | 3rd&1 | StL48 | Steven Jackson rush to the right for no gain to the StL48. Tackled by Patrick Willis. | | |
| StL | 4th&1 | StL48 | Johnny Hekker punts for 37 yards to SF15. No return. Penalty: Illegal Block on St. Louis (Craig Dahl) 10 yards. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF25 | Colin Kaepernick incomplete pass to the right intended for Frank Gore. | | |
| SF | 2nd&10 | SF25 | Frank Gore rush to the left for 4 yards to the SF29. Tackled by James Laurinaitis. | | |
| SF | 3rd&6 | SF29 | Colin Kaepernick rush to the left for 2 yards to the SF31. Tackled by James Laurinaitis. | | |
| SF | 4th&4 | SF31 | Andy Lee punts for 61 yards to StL8. Austin Pettis return for 2 yards to StL10. Tackled by C.J. Spillman. Penalty: Holding on St. Louis (Janoris Jenkins) -5 yards. | | |
| Team | Down | Spot | Play | SF | StL |
| StL | 1st&10 | StL5 | Sam Bradford pass to the right to Chris Givens for 6 yards to the StL11. Tackled by Carlos Rogers. | | |
| StL | 2nd&4 | StL11 | Steven Jackson rush to the left for a loss of 1 yard to the StL10. Tackled by Isaac Sopoaga. | | |
| StL | 3rd&5 | StL10 | Sam Bradford incomplete pass to the right intended for Steven Jackson. | | |
| StL | 4th&5 | StL10 | Johnny Hekker punts for 50 yards to SF40. No return. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF40 | Frank Gore rush to the left for 23 yards to the StL37. Tackled by Craig Dahl. | | |
| SF | 1st&10 | StL37 | Colin Kaepernick sacked at StL44 for a loss of 7 yards by Jo-Lonn Dunbar and William Hayes. | | |
| SF | 2nd&17 | StL44 | Colin Kaepernick pass to the left to Bruce Miller for 11 yards to the StL33. Tackled by Jo-Lonn Dunbar. | | |
| SF | 3rd&6 | StL33 | Colin Kaepernick rush to the left for 7 yards to the StL26. Tackled by Jo-Lonn Dunbar. | | |
| SF | 1st&10 | StL26 | Frank Gore rush to the left for 7 yards to the StL19. Tackled by Quintin Mikell. | | |
| SF | 2nd&3 | StL19 | Frank Gore rush to the right for 2 yards to the StL17. Tackled by Jermelle Cudjo. | | |
| SF | 3rd&1 | StL17 | Brandon Jacobs rush to the right for 3 yards to the StL14. Tackled by Jermelle Cudjo. | | |
| SF | 1st&10 | StL14 | Colin Kaepernick pass to the left to Bruce Miller for 6 yards to the StL8. Tackled by Jo-Lonn Dunbar. | | |
| SF | 2nd&4 | StL8 | Frank Gore rush to the right for no gain to the StL8. Tackled by Quintin Mikell. | | |
| SF | 3rd&4 | StL8 | Colin Kaepernick pass to the left to Mario Manningham for 7 yards to the StL1. Tackled by Janoris Jenkins and Craig Dahl. | | |
| SF | 1st&1 | StL1 | Frank Gore rush to the right for 1 yard for a TOUCHDOWN. | | |
| SF | | | David Akers extra point is good. | | |
| SF | | | Drive Stats: 11 plays, 60 yards, 6min 33sec | 7 | 0 |
| Team | Down | Spot | Play | SF | StL |
| SF | | | David Akers kicks off to the StL0. Touchback. | | |
| StL | 1st&10 | StL20 | Steven Jackson rush up the middle for no gain to the StL20. Tackled by Justin Smith. | | |
| StL | 2nd&10 | StL20 | Sam Bradford pass to the left to Chris Givens for 8 yards to the StL28. Tackled by Donte Whitner. | | |
| StL | 3rd&2 | StL28 | Sam Bradford incomplete pass to the right intended for Chris Givens. | | |
| StL | 4th&2 | StL28 | Johnny Hekker punts for 32 yards to SF40. No return. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF40 | Brandon Jacobs rush to the left for 2 yards to the SF42. Tackled by Kendall Langford. | | |
| SF | 2nd&8 | SF42 | Colin Kaepernick pass to the right to Randy Moss for 16 yards to the StL42. Tackled by Cortland Finnegan. | | |
| |
| Second Quarter |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | StL42 | Penalty: Holding on San Francisco (Joe Staley) -10 yards. | | |
| SF | 1st&20 | SF48 | Colin Kaepernick pass to the middle to Michael Crabtree for 5 yards to the StL47. Tackled by Rocky McIntosh. | | |
| SF | 2nd&15 | StL47 | Colin Kaepernick pass to the right to Mario Manningham for 5 yards to the StL42. Tackled by Jo-Lonn Dunbar. | | |
| SF | 3rd&10 | StL42 | Colin Kaepernick rush to the left for 1 yard to the StL41. Tackled by James Laurinaitis. | | |
| SF | 4th&9 | StL41 | Andy Lee punts for 31 yards to StL10. No return. | | |
| Team | Down | Spot | Play | SF | StL |
| StL | 1st&10 | StL10 | Daryl Richardson rush to the left for 2 yards to the StL12. Tackled by NaVorro Bowman. | | |
| StL | 2nd&8 | StL12 | Sam Bradford pass to the left to Lance Kendricks for 9 yards to the StL21. Tackled by Patrick Willis. | | |
| StL | 1st&10 | StL21 | San Francisco 49ers timeout. | | |
| StL | 1st&10 | StL21 | Sam Bradford pass to the right to Daryl Richardson for 1 yard to the StL22. Tackled by Ahmad Brooks. | | |
| StL | 2nd&9 | StL22 | Penalty: Holding on St. Louis (Scott Wells) -10 yards. | | |
| StL | 2nd&19 | StL12 | Sam Bradford pass to the right to Daryl Richardson for 4 yards to the StL16. Tackled by NaVorro Bowman. | | |
| StL | 3rd&15 | StL16 | Sam Bradford pass to the left to Lance Kendricks for 3 yards to the StL19. Tackled by Carlos Rogers. | | |
| StL | 4th&12 | StL19 | Johnny Hekker punts for 63 yards to SF18. Ted Ginn Jr. return for 6 yards to SF24. Tackled by Rodney McLeod. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF24 | Colin Kaepernick pass to the left to Vernon Davis for 6 yards to the SF30. Tackled by Rocky McIntosh. | | |
| SF | 2nd&4 | SF30 | Frank Gore rush to the left for 1 yard to the SF31. Tackled by James Laurinaitis. | | |
| SF | 3rd&3 | SF31 | Colin Kaepernick pass to the left to Delanie Walker for 7 yards to the SF38. Tackled by Janoris Jenkins. | | |
| SF | 1st&10 | SF38 | Colin Kaepernick pass to the right to Michael Crabtree for 11 yards to the SF49. Tackled by Jo-Lonn Dunbar and Cortland Finnegan. | | |
| SF | 1st&10 | SF49 | Frank Gore rush to the left for 2 yards to the StL49. Tackled by James Laurinaitis. | | |
| SF | 2nd&8 | StL49 | Frank Gore rush to the right for a loss of 3 yards to the SF48. Tackled by William Hayes. | | |
| SF | 3rd&11 | SF48 | Colin Kaepernick incomplete pass to the right intended for Michael Crabtree. | | |
| SF | 4th&11 | SF48 | Penalty: False Start on San Francisco (C.J. Spillman) -5 yards. | | |
| SF | 4th&16 | SF43 | Andy Lee punts for 53 yards to StL4. Austin Pettis return for 14 yards to StL18. Tackled by Michael Wilhoite. | | |
| Team | Down | Spot | Play | SF | StL |
| StL | 1st&10 | StL18 | Steven Jackson rush up the middle for a loss of 2 yards to the StL16. Tackled by Justin Smith. | | |
| StL | 2nd&12 | StL16 | Sam Bradford sacked at StL10 for a loss of 6 yards by Aldon Smith. | | |
| StL | 3rd&18 | StL10 | Steven Jackson rush to the right for 1 yard to the StL11. Tackled by Donte Whitner. | | |
| StL | 4th&17 | StL11 | Johnny Hekker punts for 50 yards to SF39. Ted Ginn Jr. - no return. Tackled by Cory Harkey. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF39 | Colin Kaepernick incomplete pass to the right intended for Michael Crabtree. | | |
| SF | 2nd&10 | SF39 | Frank Gore rush up the middle for 3 yards to the SF42. Tackled by Jermelle Cudjo. | | |
| SF | 3rd&7 | SF42 | Two Minute Warning. | | |
| SF | 3rd&7 | SF42 | Colin Kaepernick incomplete pass to the right intended for Mario Manningham. | | |
| SF | 4th&7 | SF42 | Andy Lee punts for 50 yards to StL8. Austin Pettis return for 5 yards to StL13. Tackled by Tramaine Brock. | | |
| Team | Down | Spot | Play | SF | StL |
| StL | 1st&10 | StL13 | Sam Bradford pass to the right to Chris Givens for 7 yards to the StL20. Tackled by Chris Culliver. | | |
| StL | 2nd&3 | StL20 | Sam Bradford pass to the middle to Steven Jackson for 5 yards to the StL25. Tackled by NaVorro Bowman. | | |
| StL | 1st&10 | StL25 | St. Louis Rams timeout. | | |
| StL | 1st&10 | StL25 | Sam Bradford pass to the right to Chris Givens for 7 yards to the StL32. Tackled by Chris Culliver. | | |
| StL | 2nd&3 | StL32 | Sam Bradford pass to the right to Lance Kendricks for 20 yards to the SF48. Tackled by Donte Whitner. | | |
| StL | 1st&10 | SF48 | Sam Bradford incomplete pass to the middle. | | |
| StL | 2nd&10 | SF48 | Sam Bradford pass to the right to Steven Jackson for 8 yards to the SF40. Tackled by NaVorro Bowman. | | |
| StL | 3rd&2 | SF40 | Sam Bradford incomplete pass to the right intended for Steve Smith. | | |
| StL | 4th&2 | SF40 | St. Louis Rams timeout. | | |
| StL | 4th&2 | SF40 | 58 yard field goal attempt by Greg Zuerlein is NO GOOD. Holder: Johnny Hekker. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF48 | Colin Kaepernick pass to the right to Ted Ginn Jr. for 1 yard to the SF49. Tackled by Trumaine Johnson. | | |
| SF | 2nd&9 | SF49 | Colin Kaepernick sacked at SF40 for a loss of 9 yards by Eugene Sims. | | |
| SF | 3rd&18 | SF40 | San Francisco 49ers timeout. | | |
| SF | 3rd&18 | SF40 | Colin Kaepernick sacked at SF39 for a loss of 1 yard by William Hayes. | | |
| SF | 4th&19 | SF39 | St. Louis Rams timeout. | | |
| SF | 4th&19 | SF39 | Colin Kaepernick incomplete pass to the left intended for Randy Moss. | | |
| Team | Down | Spot | Play | SF | StL |
| |
| Third Quarter |
| Team | Down | Spot | Play | SF | StL |
| StL | | | Greg Zuerlein kicks off to the SF0. Touchback. | | |
| SF | 1st&10 | SF20 | Colin Kaepernick rush to the right for 6 yards to the SF26. Tackled by Rocky McIntosh. | | |
| SF | 2nd&4 | SF26 | Frank Gore rush to the left for 1 yard to the SF27. Tackled by Chris Long. | | |
| SF | 3rd&3 | SF27 | Colin Kaepernick incomplete pass to the right intended for Michael Crabtree. | | |
| SF | 4th&3 | SF27 | Andy Lee punts for 51 yards to StL22. No return. | | |
| Team | Down | Spot | Play | SF | StL |
| StL | 1st&10 | StL22 | Sam Bradford pass to the left to Chris Givens for 11 yards to the StL33. Tackled by Dashon Goldson. | | |
| StL | 1st&10 | StL33 | Steven Jackson rush up the middle for 2 yards to the StL35. Tackled by Ray McDonald. | | |
| StL | 2nd&8 | StL35 | Sam Bradford pass to the left to Chris Givens for 8 yards to the StL43. Tackled by Tarell Brown. | | |
| StL | 1st&10 | StL43 | Sam Bradford pass to the right to Steven Jackson for 20 yards to the SF37. Tackled by Ahmad Brooks. | | |
| StL | 1st&10 | SF37 | Steven Jackson rush to the right for 2 yards to the SF35. Tackled by Chris Culliver and NaVorro Bowman. | | |
| StL | 2nd&8 | SF35 | Sam Bradford incomplete pass to the left intended for Isaiah Pead. | | |
| StL | 3rd&8 | SF35 | Sam Bradford pass to the right to Steven Jackson for 22 yards to the SF13. Tackled by Carlos Rogers. | | |
| StL | 1st&10 | SF13 | Daryl Richardson rush up the middle for 1 yard to the SF12. Tackled by Will Tukuafu. | | |
| StL | 2nd&9 | SF12 | Penalty: False Start on St. Louis (Rodger Saffold) -5 yards. | | |
| StL | 2nd&14 | SF17 | Sam Bradford rush to the right for 6 yards to the SF11. Tackled by Carlos Rogers. | | |
| StL | 3rd&8 | SF11 | Sam Bradford pass to the left to Austin Pettis for 7 yards to the SF4. Tackled by Carlos Rogers. | | |
| StL | 4th&1 | SF4 | St. Louis Rams timeout. | | |
| StL | 4th&1 | SF4 | Sam Bradford incomplete pass to the right intended for Austin Pettis defensed by Tarell Brown. | | |
| SF | 1st&10 | SF4 | Frank Gore rush up the middle for no gain to the SF4. Tackled by James Laurinaitis. | | |
| SF | 2nd&10 | SF4 | Frank Gore rush to the left for a loss of 1 yard to the SF3. Tackled by Michael Brockers. | | |
| SF | 3rd&11 | SF3 | Colin Kaepernick pass to the left to Mario Manningham for 14 yards to the SF17. Tackled by Craig Dahl. | | |
| SF | 1st&10 | SF17 | Colin Kaepernick incomplete pass to the right. Penalty: Intentional Grounding on San Francisco (Colin Kaepernick) -17 yards. Safety. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | | | Andy Lee kicks off to the StL17. Austin Pettis return for 13 yards to StL30. Tackled by Will Tukuafu. | | |
| StL | 1st&10 | StL30 | Penalty: Holding on San Francisco (Justin Smith) 5 yards. | | |
| StL | 1st&10 | StL35 | Steven Jackson rush to the right for no gain to the StL35. Tackled by Ahmad Brooks. | | |
| StL | 2nd&10 | StL35 | Steven Jackson rush to the right for no gain to the StL35. Tackled by Justin Smith. | | |
| StL | 3rd&10 | StL35 | Sam Bradford pass to the right to Chris Givens for 9 yards to the StL44. Tackled by Chris Culliver. | | |
| StL | 4th&1 | StL44 | Johnny Hekker punts for 55 yards to SF1. No return. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF1 | Penalty: Holding on San Francisco (Mike Iupati) 0 yards. | | |
| SF | 1st&10 | SF1 | Colin Kaepernick pass to the left to Michael Crabtree for 10 yards to the SF11. Tackled by Janoris Jenkins. | | |
| SF | 1st&10 | SF11 | Penalty: Illegal Motion on San Francisco (Will Tukuafu) -5 yards. | | |
| SF | 1st&15 | SF6 | Colin Kaepernick pass to the right to Michael Crabtree for 22 yards to the SF28. Tackled by Cortland Finnegan. | | |
| |
| Fourth Quarter |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF28 | Frank Gore rush to the left for 2 yards to the SF30. Tackled by Kendall Langford. | | |
| SF | 2nd&8 | SF30 | Penalty: Roughing Passer on St. Louis (Robert Quinn) 15 yards. | | |
| SF | 1st&10 | SF45 | Frank Gore rush up the middle for no gain to the SF45. Tackled by Jermelle Cudjo. | | |
| SF | 2nd&10 | SF45 | San Francisco 49ers timeout. | | |
| SF | 2nd&10 | SF45 | Frank Gore rush to the right for 2 yards to the SF47. Tackled by Rocky McIntosh. | | |
| SF | 3rd&8 | SF47 | Colin Kaepernick pass to the left to Michael Crabtree for 30 yards to the StL23. Tackled by Quintin Mikell. | | |
| SF | 1st&10 | StL23 | Colin Kaepernick pass to the right to Michael Crabtree for 7 yards to the StL16. Tackled by Cortland Finnegan. | | |
| SF | 2nd&3 | StL16 | Colin Kaepernick incomplete pass to the left intended for Vernon Davis. | | |
| SF | 3rd&3 | StL16 | Colin Kaepernick pass to the left to Mario Manningham for 7 yards to the StL9. Tackled by Jo-Lonn Dunbar. | | |
| SF | 1st&9 | StL9 | Frank Gore rush to the right for a loss of 1 yard to the StL10. Tackled by Jo-Lonn Dunbar. | | |
| SF | 2nd&10 | StL10 | Colin Kaepernick rush up the middle for 1 yard to the StL9. Tackled by Eugene Sims. | | |
| SF | 3rd&9 | StL9 | Colin Kaepernick pass to the right to Mario Manningham for 4 yards to the StL5. Tackled by Jo-Lonn Dunbar. | | |
| SF | 4th&5 | StL5 | David Akers 23 yard field goal attempt is GOOD. Holder: Andy Lee. | | |
| SF | | | Drive Stats: 13 plays, 94 yards, 8min 13sec | 10 | 2 |
| Team | Down | Spot | Play | SF | StL |
| SF | | | David Akers kicks off to the StL0. Chris Givens return for 22 yards to StL19. Tackled by Darcel McBath. | | |
| StL | 1st&10 | StL19 | Steven Jackson rush to the left for 6 yards to the StL25. Tackled by Justin Smith. | | |
| StL | 2nd&4 | StL25 | Sam Bradford sacked at StL18 for a loss of 7 yards by Justin Smith. | | |
| StL | 3rd&11 | StL18 | Sam Bradford pass to the right to Steven Jackson for 14 yards to the StL32. Tackled by Chris Culliver. | | |
| StL | 1st&10 | StL32 | Sam Bradford pass to the left to Chris Givens for 9 yards to the StL41. Tackled by Carlos Rogers. | | |
| StL | 2nd&1 | StL41 | Steven Jackson rush to the right for 3 yards to the StL44. Tackled by NaVorro Bowman. | | |
| StL | 1st&10 | StL44 | Sam Bradford incomplete pass to the left intended for Lance Kendricks. | | |
| StL | 2nd&10 | StL44 | Sam Bradford pass to the left to Steve Smith for 6 yards to the StL50. Tackled by Perrish Cox and Donte Whitner. | | |
| StL | 3rd&4 | StL50 | Sam Bradford incomplete pass to the right intended for Brian Quick defensed by Chris Culliver. | | |
| StL | 4th&4 | StL50 | Johnny Hekker punts for 40 yards to SF10. No return. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF10 | Brandon Jacobs rush to the left for no gain to the SF10. Tackled by Michael Brockers. | | |
| SF | 2nd&10 | SF10 | San Francisco 49ers timeout. | | |
| SF | 2nd&10 | SF10 | Colin Kaepernick rush to the right for 7 yards to the SF17. Tackled by Rocky McIntosh. | | |
| SF | 3rd&3 | SF17 | Colin Kaepernick rush up the middle for no gain to the SF17. FUMBLE, recovered by StL (Janoris Jenkins) and returned for 2 yards for a TOUCHDOWN. | | |
| Team | Down | Spot | Play | SF | StL |
| StL | | | Penalty: False Start on St. Louis (Rodger Saffold) -5 yards. | | |
| StL | | | Sam Bradford 2 pt conversion pass to Lance Kendricks is GOOD. | | |
| StL | | | Drive Stats: 0 plays, 0 yards, 0sec | 10 | 10 |
| Team | Down | Spot | Play | SF | StL |
| StL | | | Greg Zuerlein kicks off to the SF0. Touchback. | | |
| SF | 1st&10 | SF20 | Colin Kaepernick pass to the right to Michael Crabtree for 16 yards to the SF36. Tackled by Quintin Mikell. | | |
| SF | 1st&10 | SF36 | Colin Kaepernick rush to the right for 50 yards to the StL14. Tackled by Janoris Jenkins. | | |
| SF | 1st&10 | StL14 | Two Minute Warning. | | |
| SF | 1st&10 | StL14 | Colin Kaepernick incomplete pass to the right intended for Delanie Walker. | | |
| SF | 2nd&10 | StL14 | Penalty: Holding on San Francisco (Delanie Walker) -10 yards. | | |
| SF | 2nd&20 | StL24 | Frank Gore rush to the right for a loss of 1 yard to the StL25. Tackled by Jo-Lonn Dunbar. | | |
| SF | 3rd&21 | StL25 | St. Louis Rams timeout. | | |
| SF | 3rd&21 | StL25 | Colin Kaepernick rush to the right for 10 yards to the StL15. Tackled by Quintin Mikell. | | |
| SF | 4th&11 | StL15 | David Akers 33 yard field goal attempt is GOOD. Holder: Andy Lee. | | |
| SF | | | Drive Stats: 6 plays, 65 yards, 1min 30sec | 13 | 10 |
| Team | Down | Spot | Play | SF | StL |
| SF | | | David Akers kicks off to the StL0. Touchback. | | |
| StL | 1st&10 | StL20 | Sam Bradford incomplete pass to the right intended for Lance Kendricks. | | |
| StL | 2nd&10 | StL20 | Sam Bradford rush to the left for 14 yards to the StL34. Tackled by Dashon Goldson. | | |
| StL | 1st&10 | StL34 | Sam Bradford rush to the left for 11 yards to the StL45. Tackled by Dashon Goldson. Penalty: Unnecessary Roughness on San Francisco (Dashon Goldson) 15 yards. | | |
| StL | 1st&10 | SF40 | Penalty: Illegal Formation on St. Louis -5 yards. | | |
| StL | 1st&15 | SF45 | Sam Bradford incomplete pass to the middle intended for Austin Pettis defensed by Dashon Goldson. | | |
| StL | 2nd&15 | SF45 | Sam Bradford pass to the right to Austin Pettis for 5 yards to the SF40. Tackled by Carlos Rogers. | | |
| StL | 3rd&10 | SF40 | Sam Bradford pass to the right to Chris Givens for 5 yards to the SF35. Tackled by Chris Culliver. | | |
| StL | 4th&5 | SF35 | St. Louis Rams timeout. | | |
| StL | 4th&5 | SF35 | Greg Zuerlein 53 yard field goal attempt is GOOD. Holder: Johnny Hekker. | | |
| StL | | | Drive Stats: 7 plays, 45 yards, 1min 34sec | 13 | 13 |
| Team | Down | Spot | Play | SF | StL |
| |
| Overtime |
| Team | Down | Spot | Play | SF | StL |
| SF | | | David Akers kicks off to the StL0. Touchback. | | |
| StL | 1st&10 | StL20 | Steven Jackson rush to the right for 2 yards to the StL22. Tackled by Isaac Sopoaga. | | |
| StL | 2nd&8 | StL22 | Sam Bradford pass to the left to Chris Givens for 16 yards to the StL38. Tackled by Donte Whitner. | | |
| StL | 1st&10 | StL38 | Penalty: Holding on St. Louis (Matthew Mulligan) -10 yards. | | |
| StL | 1st&20 | StL28 | Daryl Richardson rush to the left for 3 yards to the StL31. Tackled by Justin Smith. | | |
| StL | 2nd&17 | StL31 | Sam Bradford pass to the left to Daryl Richardson for 2 yards to the StL33. Tackled by NaVorro Bowman. | | |
| StL | 3rd&15 | StL33 | Sam Bradford incomplete pass to the left intended for Steven Jackson. | | |
| StL | 4th&15 | StL33 | Johnny Hekker punts for 47 yards to SF20. No return. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF20 | Colin Kaepernick pass to the left to Vernon Davis for 9 yards to the SF29. Tackled by Michael Brockers. | | |
| SF | 2nd&1 | SF29 | San Francisco 49ers timeout. | | |
| SF | 2nd&1 | SF29 | Frank Gore rush to the right for 6 yards to the SF35. Tackled by Craig Dahl. | | |
| SF | 1st&10 | SF35 | Penalty: Holding on San Francisco (Daniel Kilgore) -10 yards. | | |
| SF | 1st&20 | SF25 | Colin Kaepernick incomplete pass to the left intended for Randy Moss. | | |
| SF | 2nd&20 | SF25 | San Francisco 49ers timeout. | | |
| SF | 2nd&20 | SF25 | Frank Gore rush to the right for 1 yard to the SF26. Tackled by Jo-Lonn Dunbar. | | |
| SF | 3rd&19 | SF26 | Colin Kaepernick pass to the left to Randy Moss for 7 yards to the SF33. Tackled by James Laurinaitis. | | |
| SF | 4th&12 | SF33 | Penalty: False Start on San Francisco (Tramaine Brock) -5 yards. | | |
| SF | 4th&17 | SF28 | Andy Lee punts for 60 yards to StL12. Austin Pettis return for 15 yards to StL27. Tackled by Brian Jennings. | | |
| Team | Down | Spot | Play | SF | StL |
| StL | 1st&10 | StL27 | Sam Bradford incomplete pass to the right intended for Chris Givens. | | |
| StL | 2nd&10 | StL27 | Steven Jackson rush to the left for 6 yards to the StL33. Tackled by Dashon Goldson and Aldon Smith. | | |
| StL | 3rd&4 | StL33 | Sam Bradford pass to the left to Brian Quick for 3 yards to the StL36. Tackled by Tarell Brown. | | |
| StL | 4th&1 | StL36 | Johnny Hekker punts for 14 yards to StL50. No return. | | |
| Team | Down | Spot | Play | SF | StL |
| SF | 1st&10 | SF50 | Frank Gore rush up the middle for 5 yards to the StL45. Tackled by James Laurinaitis. | | |
| SF | 2nd&5 | StL45 | Brandon Jacobs rush to the right for 1 yard to the StL44. Tackled by Rocky McIntosh. | | |
| SF | 3rd&4 | StL44 | Colin Kaepernick pass to the left to Randy Moss for 7 yards to the StL37. Tackled by Janoris Jenkins. | | |
| SF | 1st&10 | StL37 | Frank Gore rush to the right for 2 yards to the StL35. Tackled by James Laurinaitis. | | |
| SF | 2nd&8 | StL35 | Frank Gore rush to the right for 2 yards to the StL33. Tackled by James Laurinaitis. | | |
| SF | 3rd&6 | StL33 | Colin Kaepernick incomplete pass to the left intended for Michael Crabtree. | | |
| SF | 4th&6 | StL33 | 51 yard field goal attempt by David Akers is NO GOOD. Holder: Andy Lee. | | |
| StL | 1st&10 | StL41 | Steven Jackson rush to the left for 3 yards to the StL44. Tackled by Patrick Willis. | | |
| StL | 2nd&7 | StL44 | Steven Jackson rush up the middle for 4 yards to the StL48. Tackled by Aldon Smith. | | |
| StL | 3rd&3 | StL48 | Sam Bradford pass to the left to Chris Givens for 6 yards to the SF46. Tackled by Tarell Brown. | | |
| StL | 1st&10 | SF46 | Steven Jackson rush to the right for 9 yards to the SF37. Tackled by Donte Whitner. | | |
| StL | 2nd&1 | SF37 | Two Minute Warning. | | |
| StL | 2nd&1 | SF37 | Steven Jackson rush to the right for a loss of 2 yards to the SF39. Tackled by Justin Smith. | | |
| StL | 3rd&3 | SF39 | St. Louis Rams timeout. | | |
| StL | 3rd&3 | SF39 | Steven Jackson rush to the right for 2 yards to the SF37. Tackled by NaVorro Bowman. | | |
| StL | 4th&1 | SF37 | St. Louis Rams timeout. | | |
| StL | 4th&1 | SF37 | Greg Zuerlein 54 yard field goal attempt is GOOD. Holder: Johnny Hekker. | | |
| StL | | | Drive Stats: 7 plays, 22 yards, 3min 45sec | 13 | 16 |