Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Kurt Suzuki | Juan Centeno | ||||
| First Base | Joe Mauer | |||||
| Second Base | Brian Dozier | |||||
| Shortstop | Jorge Polanco | |||||
| Third Base | Eduardo Escobar | James Beresford | ||||
| Left Field | Robbie Grossman | |||||
| Center Field | Byron Buxton | |||||
| Right Field | Max Kepler | Logan Schafer | ||||
| Designated Hitter | Miguel Sano | Kennys Vargas | ||||
| Starting Pitcher | Ervin Santana | Héctor Santiago | Kyle Gibson | José Berrios | Tyler Duffey | |
| Closer | Brandon Kintzler | |||||
| Relief Pitcher | Ryan Pressly | Michael Tonkin | Taylor Rogers | Ryan O'Rourke | J.T. Chargois | Andrew Albers |
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